Kim Hyejin, Hong Sungkyun, Kim Seungji, Oh Dayoung, Lee Siheon, Choen Sangkyung, Yoon Junghee, Choi Mincheol
Department of Veterinary Medical Imaging and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea.
J Vet Sci. 2019 Jul;20(4):e38. doi: 10.4142/jvs.2019.20.e38.
Use of a saline chaser has been reported to allow reduction of contrast dose and artifacts during computed tomography (CT) examination in humans. This study assesses the extent of contrast dose by using a saline chaser in abdominal CT scans of normal dogs. Five beagles underwent abdominal CT scans. Three protocols were applied: 600 mg I/kg iohexol without saline chaser (protocol 1), 30% lower dose of iohexol (420 mg I/kg) followed by a 10 mL saline chaser (protocol 2), and 40% lower dose of iohexol (360 mg I/kg) followed by a 10 mL saline chaser (protocol 3). Attenuation values were obtained from aorta, portal vein, and liver parenchyma. The maximum enhancement values (MEVs) in protocol 2 were significantly higher than those in protocols 1 and 3 in the aorta; no difference was seen in the portal vein in all protocols. The liver parenchymal MEVs in protocols 1 and 2 were significantly higher than those obtained in protocol 3. In this study, the use of a saline chaser and a reduced dose of contrast material did not affect vessel enhancement. In conclusion, use of a saline chaser for abdominal CT of dogs is recommended because it allows a 30% reduction of contrast dose without decreasing vascular and hepatic parenchymal enhancement.
据报道，在人类计算机断层扫描（CT）检查中使用生理盐水冲管可减少造影剂用量和伪影。本研究评估了在正常犬腹部CT扫描中使用生理盐水冲管时造影剂用量的减少程度。五只比格犬接受了腹部CT扫描。应用了三种方案：600 mg碘/千克碘海醇且不使用生理盐水冲管（方案1），碘海醇剂量降低30%（420 mg碘/千克）并随后给予10 mL生理盐水冲管（方案2），以及碘海醇剂量降低40%（360 mg碘/千克）并随后给予10 mL生理盐水冲管（方案3）。从主动脉、门静脉和肝实质获取衰减值。方案2中主动脉的最大强化值（MEV）显著高于方案1和方案3；所有方案中门静脉的MEV无差异。方案1和方案2中肝实质的MEV显著高于方案3。在本研究中，使用生理盐水冲管和降低造影剂剂量并不影响血管强化。总之，建议在犬腹部CT中使用生理盐水冲管，因为它可使造影剂用量减少30%，同时不降低血管和肝实质的强化。
