Iikura Y, Inui H, Nagakura T, Lee T H
J Allergy Clin Immunol. 1985 Feb;75(2):285-9. doi: 10.1016/0091-6749(85)90059-4.
Seventeen children developed reproducible early and late asthmatic responses (dual reactions) after cycle ergometer exercise. There was a significant correlation between the magnitude of their early and late reactions, emphasizing the direct relationship of these events. No significant differences were observed in the clinical severity of asthma, diurnal variations in FEV1, and extent of the early reaction after exercise between children with dual responses and 19 children with single reactions. These findings suggest that the occurrence of late reactions after exercise is not determined by differences in severity of disease or baseline airway reactivity in the asthmatic subjects. This view is supported by the finding that there was no significant difference in the dose of acetylcholine necessary to elicit a 20% decrease in FEV1 between eight children with dual response and seven children with single early response after exercise. The rate of spontaneous recovery from early reactions was slower in children with dual responses, suggesting that this variable may predict development of late-phase reactions in exercise-induced asthma.
17名儿童在进行自行车测力计运动后出现了可重复的早期和晚期哮喘反应（双重反应）。他们早期和晚期反应的程度之间存在显著相关性，强调了这些事件之间的直接关系。在有双重反应的儿童和19名有单一反应的儿童之间，哮喘的临床严重程度、第一秒用力呼气容积（FEV1）的日变化以及运动后早期反应的程度均未观察到显著差异。这些发现表明，运动后晚期反应的发生并非由哮喘患者疾病严重程度或基线气道反应性的差异所决定。这一观点得到了以下发现的支持：在8名有双重反应的儿童和7名运动后有单一早期反应的儿童之间，引起FEV1下降20%所需的乙酰胆碱剂量没有显著差异。有双重反应的儿童早期反应的自发恢复速度较慢，这表明该变量可能预测运动诱发哮喘中晚期反应的发生。
