Tweeddale P M, Godden D J, Grant I W
Thorax. 1981 Aug;36(8):596-8. doi: 10.1136/thx.36.8.596.
Bronchoconstriction was induced in asthmatic patients by means of isocapnic hyperventilation with dry air. Responses both within a day and between days did not differ significantly and corresponded closely with those observed after exercise. The mean fall in forced expiratory volume in one second (FEV1) observed with both techniques was equivalent to 36%. Isocapnic hyperventilation with dry air, as used in this study, was a potent stimulus and provoked a reproducible response. The method was physically less demanding than exercise and was more acceptable to patients.
通过使用干燥空气进行等碳酸血症过度通气，在哮喘患者中诱发支气管收缩。一天内和不同天之间的反应没有显著差异，并且与运动后观察到的反应密切相关。两种技术观察到的一秒用力呼气量（FEV1）的平均下降相当于36%。本研究中使用的干燥空气等碳酸血症过度通气是一种有效的刺激，并引发了可重复的反应。该方法在体力上比运动要求更低，并且更受患者接受。
