Department of Emergency and Critical Care Medicine, Kitasato University School of Medicine; 1-15-1 Kitasato, Minami-ku, Sagamihara 252-0375, Japan.
Nutrients. 2024 Aug 25;16(17):2841. doi: 10.3390/nu16172841.
Zinc plays an important role in sepsis; however, the effectiveness of zinc supplementation and the appropriate dose remain unclear. This study aimed to verify the effectiveness of zinc supplementation and the appropriate dose in patients with sepsis.
This single-center retrospective observational study included 247 patients with sepsis from 1 April 2015 to 31 March 2023 who were receiving ventilatory management. The patients were divided into three groups according to the zinc supplementation dose: <15 mg, 15-50 mg, and ≥50 mg.
The <15 mg, 15-50 mg, and ≥50 mg groups had 28 (19%), six (21%), and 16 deaths (22%) at discharge, with no statistically significant difference ( = 0.36). No statistically significant differences were observed in the length of intensive care unit (ICU) stay ( = 0.06). A higher supplementation dose corresponded with a statistically significant increase in blood zinc concentration in the first week (38.5 ± 16.6 µg/dL, 58.8 ± 19.7 µg/dL, 74.2 ± 22.5 µg/dL, respectively; < 0.01) but not in the second or third weeks ( = 0.08, 0.19, respectively).
Zinc supplementation did not reduce the mortality rate or length of ICU stay or contribute to an increased serum zinc concentration. High-dose zinc supplementation may not be effective during acute sepsis.
锌在脓毒症中起着重要作用；然而，锌补充的效果和合适的剂量仍不清楚。本研究旨在验证锌补充在脓毒症患者中的效果和合适的剂量。
这是一项单中心回顾性观察研究，纳入了 2015 年 4 月 1 日至 2023 年 3 月 31 日期间接受通气管理的 247 例脓毒症患者。根据锌补充剂量将患者分为三组：<15mg、15-50mg 和≥50mg。
出院时<15mg、15-50mg 和≥50mg 组分别有 28 例（19%）、6 例（21%）和 16 例（22%）死亡，差异无统计学意义（ = 0.36）。三组 ICU 住院时间的差异无统计学意义（ = 0.06）。补充剂量越高，第 1 周的血锌浓度增加越显著（分别为 38.5±16.6µg/dL、58.8±19.7µg/dL、74.2±22.5µg/dL；<0.01），但第 2 周和第 3 周无显著差异（ = 0.08、0.19）。
锌补充并不能降低死亡率或 ICU 住院时间，也不能增加血清锌浓度。在急性脓毒症期间，高剂量锌补充可能无效。
