Balejko Edyta Barbara, Lichota Jarosław
Department of Commodity Sciences, Quality Assessment, Process Engineering and Human Nutrition, Faculty of Food Sciences and Fisheries, West Pomeranian University of Technology in Szczecin, 70-310 Szczecin, Poland.
Unii Lubelskiej 1, Department of General, Minimally Invasive and Gastroenterological Surgery, Independent Public Clinical Hospital No. 1 of Pomeranian Medical University in Szczecin, 71-252 Szczecin, Poland.
Nutrients. 2024 Nov 26;16(23):4038. doi: 10.3390/nu16234038.
BACKGROUND/OBJECTIVES: Adiposopathy is the cause of many secondary disorders in the function and structure of many organs and systems in the body. In the progression of obesity and the increasing dysfunction of anti-inflammatory me-diators, chronic inflammation occurs. This may be accompanied by the development of metabolic complications.
A diet with highly bioactive properties was formulated, and an element of diet therapy was introduced as a key component to support treatment in obese patients following bariatric surgery. Patients underwent a BIB (Bioenteric Intragastric Balloon) procedure. As obesity is a risk factor for cardiovascular diseases, this study aimed to regulate cardiovascular factors in adiposopathy. Anti-inflammatory dietary components with modulating properties were included, with increased bioflavonoids, vitamins A, E, C, folic acid, and synbiotics, and altered fatty acid composition.
The results showed satisfactory effects on fat reduction and the regulation of isoprostanes, plasminogen, angiotensin, prostacyclin, triglycerides, blood pressure, and blood rheology parameters. Cardiovascular co-morbidities are common in obesity. This is due to the endocrine function of adipocytes. As such, we decided to investigate the possibility of using bioactive dietary components as an adjunct to the safety of reducing prothrombotic parameters in obese patients after BIB surgery. This study hypothesised that the enrichment of the recommended diet after bariatric surgery with the addition of -3 EFAs, bioflavonoids, vitamins, and synbiotics might result in comparable or greater fat mass loss in the subjects. In addition, the use of a functional diet might show a beneficial modifying effect on antihyperglycemic parameter values. We then compared the results to those obtained among patients fed a reducing, standard diet.
Using a functional diet, a significant reduction in visceral fat was achieved. A decrease in VFA was shown to reduce whole-blood viscosity. Furthermore, this study showed a significant effect of bioactive components on pro-thrombotic parameters in obese patients.
背景/目的：脂肪组织病变是导致身体许多器官和系统功能及结构出现多种继发性疾病的原因。在肥胖进展过程中，抗炎介质功能日益失调，进而引发慢性炎症。这可能会伴随代谢并发症的发生。
制定了一种具有高生物活性的饮食方案，并将饮食疗法作为关键组成部分引入，以辅助肥胖患者在接受减肥手术后的治疗。患者接受了生物肠溶胃内球囊（BIB）手术。鉴于肥胖是心血管疾病的一个危险因素，本研究旨在调节脂肪组织病变中的心血管因素。饮食中纳入了具有调节特性的抗炎成分，增加了生物类黄酮、维生素A、E、C、叶酸和合生元，并改变了脂肪酸组成。
结果显示，该饮食方案在减少脂肪以及调节异前列腺素、纤溶酶原、血管紧张素、前列环素、甘油三酯、血压和血液流变学参数方面效果令人满意。心血管合并症在肥胖人群中很常见。这是由于脂肪细胞的内分泌功能所致。因此，我们决定研究在BIB手术后使用生物活性饮食成分作为辅助手段来降低肥胖患者血栓前参数的安全性的可能性。本研究假设，在减肥手术后推荐的饮食中添加ω-3脂肪酸、生物类黄酮、维生素和合生元，可能会使受试者的脂肪量减少程度相当或更大。此外，使用功能性饮食可能会对降糖参数值产生有益的调节作用。然后，我们将结果与食用减少热量的标准饮食的患者所得结果进行了比较。
通过使用功能性饮食，内脏脂肪显著减少。内脏脂肪面积的减少显示可降低全血粘度。此外，本研究表明生物活性成分对肥胖患者的血栓前参数有显著影响。
