Arshad Husnain, Recchia Daisy, Head Jenny, Holton Kathleen, Norton Joanna, Kivimaki Mika, Akbaraly Tasnime N
INSERM (Institut National de Santé et de Recherche Médicale), UVSQ (Université de Versailles Saint-Quentin-en-Yveline), Paris-Saclay Université, CESP (Centre de Recherche en Epidémiologie et Santé des Populations), F-75018 Paris, France.
INSERM (Institut National de Santé et de Recherche Médicale), MMDN (Mécanismes Moléculaires des Démences Neurodégénératives), Univ Montpellier, F-34095 Montpellier, France.
Nutrients. 2024 Nov 26;16(23):4062. doi: 10.3390/nu16234062.
BACKGROUND/OBJECTIVES: This study examined the association between adherence to the Mediterranean dietary approaches to stop hypertension Intervention for Neurodegenerative Delay (MIND) diet, its components, and recurrent depressive symptoms (DepSs).
The analyses included 4824 participants (73% men, mean age = 61; SD = 5.9) from the British Whitehall II cohort study. The MIND diet scores were derived from a validated 127-item food frequency questionnaire in 2002-2004. DepSs were assessed by the Center for Epidemiologic Studies Depression Scale (score ≥ 16) or by use of antidepressant drugs, and recurrence was defined as having DepSs in at least two of the four repeated measurements in the 2002-2004, 2007-2009, 2012-2013, and 2015-2016 follow-up phases.
Recurrent DepSs were observed in 13.3% of the participants over 13 years of follow-up. After adjusting for potential confounders, participants in the highest tertile of the MIND diet score (where a higher score represents a higher diet quality) had 26% lower odds of experiencing recurrent DepSs (OR = 0.74; 95% CI 0.58-0.93) compared to those in the lowest tertile. In mutually adjusted analyses of 14 MIND diet components in relation to recurrent DepSs, independent associations were observed for green leafy vegetables (OR = 0.59, 95% CI: 0.45-0.78), other vegetables (OR = 0.43, 95% CI:0.24-0.77), and berries (OR = 0.74, 95% CI: 0.61-0.89).
In this British prospective cohort, good adherence to the MIND diet, particularly to the recommendations for vegetables and berries, was associated with a lower risk of recurrent depressive symptoms, independent of socio-economic, health behavior, and health status factors, including baseline cognitive impairment and antecedents of DepSs.
背景/目的：本研究探讨坚持地中海饮食延缓神经退行性疾病高血压干预方案（MIND饮食）、其组成部分与复发性抑郁症状（DepSs）之间的关联。
分析纳入了来自英国白厅II队列研究的4824名参与者（73%为男性，平均年龄=61岁；标准差=5.9）。MIND饮食评分来自于2002年至2004年经过验证的127项食物频率问卷。DepSs通过流行病学研究中心抑郁量表（评分≥16）或使用抗抑郁药物进行评估，复发定义为在2002 - 2004年、2007 - 2009年、2012 - 2013年和2015 - 2016年随访阶段的四次重复测量中至少有两次出现DepSs。
在13年的随访中，13.3%的参与者出现复发性DepSs。在调整潜在混杂因素后，MIND饮食评分处于最高三分位数的参与者（分数越高表示饮食质量越高）与最低三分位数的参与者相比，出现复发性DepSs的几率降低了26%（比值比=0.74；95%置信区间0.58 - 0.93）。在对14种MIND饮食成分与复发性DepSs进行相互调整的分析中，发现绿叶蔬菜（比值比=0.59，95%置信区间：0.45 - 0.78）、其他蔬菜（比值比=0.43，95%置信区间：0.24 - 0.77）和浆果（比值比=0.74，95%置信区间：0.61 - 0.89）存在独立关联。
在这个英国前瞻性队列中，良好坚持MIND饮食，特别是遵循蔬菜和浆果的建议，与较低的复发性抑郁症状风险相关，独立于社会经济、健康行为和健康状况因素，包括基线认知障碍和DepSs的前驱因素。
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