Graduate Program in Health Sciences, Faculty of Medicine, Federal University of Goiás (UFG), Brazil; Faculty of Education, Federal University of Goiás (UFG), Brazil.
United Faculty of Campinas (Unicamps/Goiás), Brazil; Faculty of Education, Federal University of Goiás (UFG), Brazil.
Clin Nutr. 2021 Feb;40(2):404-411. doi: 10.1016/j.clnu.2020.05.046. Epub 2020 Jun 10.
RATIONAL & OBJECTIVE: Although the relationship between obesity, anxiety and depression is known, the clinical benefits of nutrition therapy in individuals with obesity have been scarcely studied. This study assessed the effectiveness of a traditional Brazilian diet (DieTBra) and extra virgin olive oil (EVOO) on the symptoms of anxiety and depression in severe obese participants.
This was a parallel randomized clinical trial in adults with severe obesity (Body Mass Index - BMI ≥ 35 kg/m), DietBra Trial. Participants were randomized into three intervention groups in a ratio of 1: 1: 1 and followed up for 12 weeks. The three intervention groups were: 1) DieTBra, 2) 52 mL/day EVOO, and 3) DieTBra +52 mL/day EVOO. The symptoms of anxiety and depression were assessed by the Hospital Anxiety and Depression Scale. The outcome variables were: anxiety, depression and simultaneous anxiety and depression in the same individual.
149 severe obese individuals were randomized. The mean BMI was 46.3 ± 6.5 kg/m with a mean age of 38.9 ± 8.7 years. After randomization, individuals on medication for depression and anxiety were excluded, totaling 129 at baseline, with 44:43:42 per group. At the end of 12 weeks 113 individuals completed the study. There was a significant reduction of symptoms for the three groups: EVOO, DieTBra and DieTBra + EVOO, respectively: anxiety 38.23% (p = 0.019), 45.83% (p=<0.014), 33.33% (p < 0.013) depression 55.17% (p=<0.001), 50.00% (p=<0.007), 34.61% (p=<0.035), and anxiety/depression 57.69% (p=<0.001), 66.67% (p=<0.014), 27.78% (p=<0.013).
Both DieTBra and olive oil interventions were effective in reducing symptoms of anxiety and depression in severe obese adults. These interventions can be integrated with clinical protocols for treatment of symptoms of anxiety and depression in severe obese individuals.
Clinicaltrials.gov NCT02463435.
尽管肥胖、焦虑和抑郁之间的关系已为人所知，但营养疗法在肥胖个体中的临床获益尚未得到充分研究。本研究评估了传统巴西饮食（DieTBra）和特级初榨橄榄油（EVOO）对重度肥胖参与者焦虑和抑郁症状的影响。
这是一项在严重肥胖（体重指数 - BMI≥35kg/m）成人中进行的平行随机临床试验，即 DietBra 试验。参与者按照 1:1:1 的比例随机分为三组，并随访 12 周。三组干预措施分别为：1）DieTBra，2）每天 52 毫升 EVOO，3）DieTBra+每天 52 毫升 EVOO。采用医院焦虑抑郁量表评估焦虑和抑郁症状。主要结局变量为：个体同时出现的焦虑、抑郁和焦虑/抑郁共病。
共纳入 149 例严重肥胖患者，平均 BMI 为 46.3±6.5kg/m，平均年龄为 38.9±8.7 岁。随机分组后，排除正在服用抗抑郁药和抗焦虑药的患者，共纳入 129 例患者，每组 44 例、43 例和 42 例。12 周后，共有 113 例患者完成研究。三组患者的症状均有显著改善：EVOO 组、DieTBra 组和 DieTBra+EVOO 组的焦虑症状分别改善了 38.23%（p=0.019）、45.83%（p<0.014）和 33.33%（p<0.013）；抑郁症状分别改善了 55.17%（p<0.001）、50.00%（p<0.007）和 34.61%（p<0.035）；焦虑/抑郁共病症状分别改善了 57.69%（p<0.001）、66.67%（p<0.014）和 27.78%（p<0.013）。
DieTBra 和橄榄油干预均能有效减轻重度肥胖成年人的焦虑和抑郁症状。这些干预措施可以与严重肥胖个体的焦虑和抑郁症状的临床治疗方案相结合。
Clinicaltrials.gov NCT02463435。
