Ranneh Yazan, Bedir Alaa S, Abu-Elsaoud Abdelghafar M, Al Raish Seham
Department of Nutrition and Dietetics, College of Pharmacy, Al-Ain University, Al-Ain P.O. Box 64141, United Arab Emirates.
Department of Nutrition, College of Medicine and Health Science, United Arab Emirates University, Al Ain 15551, United Arab Emirates.
Nutrients. 2024 Nov 29;16(23):4150. doi: 10.3390/nu16234150.
Non-alcoholic fatty liver disease (NAFLD) has recently emerged as a challenging metabolic disorder with a strong emphasis on its prevention and management. Polyphenols, a group of naturally occurring plant compounds, have been associated with a decreased risk of various metabolic disorders related to NAFLD. The current systematic review aims to critically assess evidence about the ameliorative effect of polyphenol supplementation on NAFLD patients. A PRISMA systematic search appraisal was conducted in PubMed, Scopus, Web of Science Core Collection, and all relevant studies published prior to April 2024 and met the inclusion criteria were included. Twenty-nine randomized clinical trials (RCTs) comprised 1840 NAFLD patients. The studies primarily examined eleven phenolic compounds, including turmeric, curcumin, resveratrol, genistein, catechin, green tea extract, hesperidin, and silymarin. Turmeric and curcumin decreased liver enzymes, inflammatory cytokines, lipid profile, insulin resistance, and NAFLD score, while resveratrol did not present consistent results across all the studies. Most studies on silymarin showed a reduction in liver enzymes and lipid profile; however, no changes were observed in inflammatory cytokine levels. The dietary supplementation of hesperidin and naringenin or green tea extract caused improvements in liver enzyme, lipid profile, and inflammatory cytokine, while genistein supplementation did not modulate blood lipid profile. In conclusion, dietary supplementation of polyphenols could potentially prevent and ameliorate NAFLD. Still, the inconsistent results across the included RCTs require further clinical research to establish optimal dosage and duration.
非酒精性脂肪性肝病（NAFLD）最近已成为一种具有挑战性的代谢紊乱疾病，其预防和管理受到高度重视。多酚是一类天然存在的植物化合物，与NAFLD相关的各种代谢紊乱风险降低有关。本系统评价旨在严格评估补充多酚对NAFLD患者改善作用的证据。在PubMed、Scopus、Web of Science核心合集进行了PRISMA系统检索评估，并纳入了2024年4月之前发表的所有符合纳入标准的相关研究。29项随机临床试验（RCT）共纳入1840例NAFLD患者。这些研究主要检测了11种酚类化合物，包括姜黄、姜黄素、白藜芦醇、染料木黄酮、儿茶素、绿茶提取物、橙皮苷和水飞蓟素。姜黄和姜黄素可降低肝酶、炎性细胞因子、血脂、胰岛素抵抗和NAFLD评分，而白藜芦醇在所有研究中结果并不一致。大多数关于水飞蓟素的研究显示肝酶和血脂降低；然而，炎性细胞因子水平未观察到变化。膳食补充橙皮苷和柚皮苷或绿茶提取物可改善肝酶、血脂和炎性细胞因子，而补充染料木黄酮并未调节血脂水平。总之，膳食补充多酚可能预防和改善NAFLD。然而，纳入的RCT结果不一致，需要进一步的临床研究来确定最佳剂量和疗程。
