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基于非靶向代谢组学的芹黄素和白杨素治疗潜力预测。

Untargeted Metabolomics Based Prediction of Therapeutic Potential for Apigenin and Chrysin.

机构信息

Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, IL 60515, USA.

Department of Biomedical Sciences, College of Graduate Studies, Midwestern University, Downers Grove, IL 60515, USA.

出版信息

Int J Mol Sci. 2023 Feb 17;24(4):4066. doi: 10.3390/ijms24044066.

DOI:10.3390/ijms24044066
PMID:36835484
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9967419/
Abstract

The prominent flavonoids apigenin and chrysin have been demonstrated to have systemic benefits. Our previous work was first to establish the impact of apigenin and chrysin on cellular transcriptome. In the current study, we have revealed the ability of apigenin and chrysin to alter the cellular metabolome based on our untargeted metabolomics. Based on our metabolomics data, both these structurally related flavonoids demonstrate diverging and converging properties. Apigenin demonstrated the potential to possess anti-inflammatory and vasorelaxant properties through the upregulation of intermediate metabolites of alpha-linolenic acid and linoleic acid pathways. Chrysin, on the other hand, exhibited abilities to inhibit protein and pyrimidine synthesis along with downregulation of gluconeogenesis pathways based on the altered metabolites detected. Chrysin-mediated metabolite changes are mostly due to its ability to modulate L-alanine metabolism and the urea cycle. On the other hand, both the flavonoids also demonstrated converging properties. Apigenin and chrysin were able to downregulate metabolites involved in cholesterol biosynthesis and uric acid synthesis, namely 7-dehydrocholesterol and xanthosine, respectively. This work will provide understanding regarding the diverse therapeutic potential of these naturally occurring flavonoids and help us in curbing an array of metabolic complications.

摘要

已证实黄酮类化合物芹菜素和白杨素具有全身益处。我们之前的工作首先确定了芹菜素和白杨素对细胞转录组的影响。在当前的研究中，我们根据非靶向代谢组学揭示了芹菜素和白杨素改变细胞代谢组的能力。基于我们的代谢组学数据，这两种结构相关的黄酮类化合物表现出不同的和趋同的特性。通过上调α-亚麻酸和亚油酸途径的中间代谢物，芹菜素显示出具有抗炎和血管舒张特性的潜力。另一方面，白杨素表现出抑制蛋白质和嘧啶合成的能力，同时下调糖异生途径，这是基于检测到的代谢物变化。白杨素介导的代谢物变化主要归因于其调节 L-丙氨酸代谢和尿素循环的能力。另一方面，这两种黄酮类化合物也表现出趋同的特性。芹菜素和白杨素能够下调胆固醇生物合成和尿酸合成涉及的代谢物，分别为 7-脱氢胆固醇和黄嘌呤核苷。这项工作将有助于理解这些天然存在的黄酮类化合物的多样化治疗潜力，并帮助我们抑制一系列代谢并发症。

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