Gu Jianxia, Lang Shuting, Jin Zhanbin, Wei Tingting
Department of Chemistry, Xinzhou Normal University, Xinzhou 034000, China.
Molecules. 2024 Nov 23;29(23):5534. doi: 10.3390/molecules29235534.
The design and construction of dual-functional and high-efficiency electrochemical sensors are necessary for quantitative detection. In this work, a zinc-based metal-organic framework (MOF-5) and multi-walled carbon nanotubes (MWCNTs) were combined in situ through a simple solvothermal reaction to obtain an MOF-5@MWCNTs composite. The composite exhibits a large surface area, hierarchical pore structure, excellent conductivity, and enhanced electrochemical performance in the detection of acetaminophenol (AP) and dopamine (DA). Remarkably, the synergistic effects between MOF-5 and MWCNTs enable the electrochemical sensor based on the MOF-5@MWCNTs composite to quantitatively determine AP and DA at trace levels. Under optimal conditions, the proposed sensor features relatively wide linear ranges of 0.005-600 μM and 0.1-60 μM for AP and DA, respectively, with very low detection limits (LODs) of 0.061 μM and 0.0075 μM for AP and DA. Importantly, this electrochemical sensor demonstrates excellent reproducibility, stability, and anti-interference ability, making it suitable for practical applications in the detection of AP and DA in urine and tap water samples with acceptable recoveries. The successful integration of MOF-5 with MWCNTs results in a robust and versatile electrochemical sensing platform for the rapid and reliable detection of AP and DA at trace levels.
设计和构建双功能高效电化学传感器对于定量检测至关重要。在本工作中，通过简单的溶剂热反应将锌基金属有机框架（MOF-5）和多壁碳纳米管（MWCNT）原位结合，得到MOF-5@MWCNT复合材料。该复合材料具有大表面积、分级孔结构、优异的导电性，并且在对乙酰氨基酚（AP）和多巴胺（DA）的检测中展现出增强的电化学性能。值得注意的是，MOF-5与MWCNT之间的协同效应使基于MOF-5@MWCNT复合材料的电化学传感器能够定量测定痕量水平的AP和DA。在最佳条件下，所提出的传感器对AP和DA的线性范围分别相对较宽，为0.005 - 600 μM和0.1 - 60 μM，AP和DA的检测限（LOD）极低，分别为0.061 μM和0.0075 μM。重要的是，这种电化学传感器具有出色的重现性、稳定性和抗干扰能力，使其适用于尿液和自来水样品中AP和DA检测的实际应用，回收率良好。MOF-5与MWCNT的成功整合产生了一个强大且通用的电化学传感平台，用于快速可靠地检测痕量水平的AP和DA。
