Synthesis, Crystal Structures, Antimicrobial Activity, and Acute Toxicity Evaluation of Chiral Zn(II) Schiff Base Complexes.

Four mononuclear bioefficient zinc coordination complexes Zn(NN) (-) involving chiral bidentate Schiff base ligands have been synthesized and characterized by IR, H, and C NMR spectroscopy and mass spectrometry. X-ray crystal structures of three of the zinc complexes revealed that the zinc metal ion is hexacoordinated, exhibiting a distorted octahedral geometry where both the nitrogen atoms (NN = pyridyl and imine) of imines are coordinated to the central zinc ion. The isolated zinc complexes were evaluated for their antimicrobial activity in vitro against , , and , displaying varying levels of growth inhibition. An acute toxicity test conducted using and Swiss albino mice showed that the zinc complexes - were non-toxic towards at concentrations below 414, 564, 350, and 385 µM, respectively, and did not affect liver biochemical parameters, although pyknosis was induced in hepatocytes of the treated mice.