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从[植物名称]根部绿色合成银纳米颗粒（CM-AgNPs）以提高对癌细胞的细胞毒性作用并具有抗菌和抗氧化活性。 （注：原文中“from the Root of ”后面缺少植物名称）

Green Synthesis of Silver Nanoparticles (CM-AgNPs) from the Root of for Improving the Cytotoxicity Effect in Cancer Cells with Antibacterial and Antioxidant Activities.

作者信息

Wang Dandan, Ke Haijing, Wang Hongtao, Shen Jingyu, Jin Yan, Lu Bo, Wang Bingju, Li Shuang, Li Yao, Im Wan Taek, Siddiqi Muhammad Zubair, Zhu Haibo

机构信息

College of Life Sciences, Yantai University, Yantai 264005, China.

School of Life Science, Nantong University, Nantong 226019, China.

出版信息

Molecules. 2024 Nov 30;29(23):5682. doi: 10.3390/molecules29235682.

DOI:10.3390/molecules29235682
PMID:39683843
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11643779/
Abstract

The unique properties of silver nanoparticles (AgNPs), such as size, surface charge, and the ability to release silver ions, contribute to DNA damage, inducing of oxidative stress, and apoptosis in cancer cells. Thus, the potential application of AgNPs in the field of biomedicine, and cancer therapy are rapidly increasing day by day. Therefore, in this study, AgNPs were synthesized by extract of , and then the synthesized CM-AgNPs were fully characterized. The biological activity of CM-AgNPs was investigated for antibacterial, antioxidant, and anticancer activities. The cytotoxic activity of CM-AgNPs was tested for various kinds of cancer cells including MKN45 gastric cancer cells, HCT116 human colon cancer cells, A549 human lung cancer cells, and HepG2 liver cancer cells. Among these cancer cells, the induced apoptosis activity of CM-AgNPs on HCT116 cancer cells was better and was used for further investigation. Besides, the CM-AgNPs exhibited great antioxidant activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) with 50% free radical scavenging activity, and CM-AgNPs also showed a significant antibacterial activity against and . Thus, our pilot data demonstrated that the green synthesis of CM-AgNPs would be considered a good candidate for the treatment of HCT116 cancer cells, with its strong antioxidant activity and antibacterial effects.

摘要

银纳米颗粒（AgNPs）的独特性质，如尺寸、表面电荷以及释放银离子的能力，会导致DNA损伤、诱导氧化应激并促使癌细胞凋亡。因此，AgNPs在生物医学和癌症治疗领域的潜在应用正日益迅速增加。所以，在本研究中，通过[提取物名称]提取物合成了AgNPs，然后对合成的CM - AgNPs进行了全面表征。研究了CM - AgNPs的抗菌、抗氧化和抗癌生物活性。测试了CM - AgNPs对包括MKN45胃癌细胞、HCT116人结肠癌细胞、A549人肺癌细胞和HepG2肝癌细胞在内的多种癌细胞的细胞毒性活性。在这些癌细胞中，CM - AgNPs对HCT116癌细胞的诱导凋亡活性较好，并用于进一步研究。此外，CM - AgNPs对1,1 - 二苯基 - 2 - 苦基肼（DPPH）表现出强大的抗氧化活性，自由基清除活性达50%，并且CM - AgNPs对[细菌名称1]和[细菌名称2]也显示出显著的抗菌活性。因此，我们的初步数据表明，CM - AgNPs的绿色合成因其强大的抗氧化活性和抗菌作用，有望成为治疗HCT116癌细胞的良好候选物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2441/11643779/6f6586cc2e31/molecules-29-05682-g015.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2441/11643779/630ed98de4d7/molecules-29-05682-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2441/11643779/e5fd247a0c2c/molecules-29-05682-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2441/11643779/b76bdc259d9e/molecules-29-05682-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2441/11643779/b2cec0efc518/molecules-29-05682-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2441/11643779/6f6586cc2e31/molecules-29-05682-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2441/11643779/6c13a1d6ee74/molecules-29-05682-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2441/11643779/f636d0f851d5/molecules-29-05682-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2441/11643779/1e0ef1ece04c/molecules-29-05682-g003a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2441/11643779/d33e18c3bb06/molecules-29-05682-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2441/11643779/2a7edd40db60/molecules-29-05682-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2441/11643779/0f03249ba7a0/molecules-29-05682-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2441/11643779/a654bf941529/molecules-29-05682-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2441/11643779/32c096065ce3/molecules-29-05682-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2441/11643779/b6df289b505d/molecules-29-05682-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2441/11643779/dc22c18ad823/molecules-29-05682-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2441/11643779/630ed98de4d7/molecules-29-05682-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2441/11643779/e5fd247a0c2c/molecules-29-05682-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2441/11643779/b76bdc259d9e/molecules-29-05682-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2441/11643779/b2cec0efc518/molecules-29-05682-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2441/11643779/6f6586cc2e31/molecules-29-05682-g015.jpg

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