Mahoney J R, Beutler B A, Le Trang N, Vine W, Ikeda Y, Kawakami M, Cerami A
J Immunol. 1985 Mar;134(3):1673-5.
RAW 264.7 cells upon stimulation with lipopolysaccharide secrete a protein mediator(s) that suppresses lipoprotein lipase activity in differentiated 3T3-L1 cells. The mediator(s), which is absent from unstimulated culture supernatants, is nondialyzable and thermolabile. Preliminary characterization suggests that this mediator(s) may be the same as that previously found in medium from lipopolysaccharide-treated thioglycollate-elicited mouse peritoneal macrophage cultures.
用脂多糖刺激后的RAW 264.7细胞分泌一种蛋白质介质，该介质可抑制分化的3T3-L1细胞中的脂蛋白脂肪酶活性。这种介质在未刺激的培养上清液中不存在，不可透析且对热不稳定。初步表征表明，这种介质可能与先前在脂多糖处理的巯基乙酸诱导的小鼠腹腔巨噬细胞培养物的培养基中发现的介质相同。
