Gaspari A A, Rietschel R L
J Invest Dermatol. 1985 Feb;84(2):126-9. doi: 10.1111/1523-1747.ep12275361.
A polar photoproduct of cholesterol oxidation, 7-ketocholesterol, was able to inhibit in a dose-dependent manner the mouse ear-swelling response to irritants such as croton oil or cantharidin. Its anti-inflammatory properties were much less than equivalent concentrations of hydrocortisone, but the oxidized sterol did not induce any systemic effects (as measured by thymolytic activity), as did topical hydrocortisone. It is concluded that 7-ketocholesterol has weak anti-inflammatory activity, and its mode of action may be different from that of glucocorticoids.
胆固醇氧化的一种极性光产物7-酮胆固醇能够以剂量依赖的方式抑制小鼠耳部对巴豆油或斑蝥素等刺激物的肿胀反应。其抗炎特性远低于同等浓度的氢化可的松，但这种氧化固醇不像局部使用的氢化可的松那样会引起任何全身效应（通过胸腺溶解活性来衡量）。结论是，7-酮胆固醇具有微弱的抗炎活性，其作用方式可能与糖皮质激素不同。
