Berendt R F, Jaax N K
J Lab Clin Med. 1985 Jan;105(1):124-31.
Influenza virus administered intranasally to AKR/J mice, followed 3 days later by Legionella pneumophila inoculated intranasally, caused significantly greater mortality than did either of the two agents administered alone. Viable concentrations of both bacteria and viruses dropped in sequentially infected animals, despite the ultimate fatal outcome. Viral concentrations, however, did not decrease as rapidly in sequentially infected as in singly infected mice. Histopathologic lesions were consistent with viral replication aided by elaboration of a bacterial toxin. This observation contrasts with the more commonly observed sequence in which the bacterium proliferates after the virus interferes with host defense. Cell-free preparations were found to have toxic activity.
将流感病毒经鼻内接种给AKR/J小鼠，3天后再经鼻内接种嗜肺军团菌，其导致的死亡率显著高于单独接种这两种病原体中的任何一种。尽管最终会导致致命后果，但在顺序感染的动物中，细菌和病毒的活菌浓度均下降。然而，与单独感染的小鼠相比，病毒浓度在顺序感染的小鼠中下降得并不那么快。组织病理学病变与细菌毒素释放辅助的病毒复制一致。这一观察结果与更常见的顺序相反，在后者中，细菌在病毒干扰宿主防御后增殖。发现无细胞制剂具有毒性活性。
