Odiase Peace, Ma Jonathan, Ranganathan Sruthi, Ogunkua Olugbemiga, Turner Winston B, Marshall Dana, Ochieng Josiah
Department of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College, Nashville, TN 37208, USA.
College of Arts and Science, Vanderbilt University, Nashville, TN 37203, USA.
Int J Mol Sci. 2024 Nov 30;25(23):12918. doi: 10.3390/ijms252312918.
Fetuin-A, also known as alpha-2-Heremans-Schmid-glycoprotein (Ahsg), is a multifunctional molecule with diverse roles in biological processes such as mineralization, tumor growth, and inflammation. This review explores the involvement of Ahsg in various cancers, including liver, breast, prostate, colorectal, brain, osteosarcoma, and lung cancers. In many cancer types, Ahsg promotes tumor growth, invasion, and metastasis through various mechanisms, including cellular adhesion, spreading, chemotaxis, and modulation of cell-growth signaling pathways. Additionally, Ahsg has been implicated in the regulation of inflammatory cytokine production, making it a potential marker of inflammation in cancer. The complex interplay between Ahsg and cancer progression highlights its potential as a diagnostic biomarker and therapeutic target in various cancers. However, further research is needed to fully elucidate the mechanisms of action of Ahsg in cancer and to explore its clinical implications in cancer diagnosis, prognosis, and treatment.
胎球蛋白-A，也称为α-2-赫里曼斯-施密德糖蛋白（Ahsg），是一种多功能分子，在矿化、肿瘤生长和炎症等生物过程中发挥着多种作用。本综述探讨了Ahsg在包括肝癌、乳腺癌、前列腺癌、结直肠癌、脑癌、骨肉瘤和肺癌在内的各种癌症中的作用。在许多癌症类型中，Ahsg通过多种机制促进肿瘤生长、侵袭和转移，包括细胞黏附、扩散、趋化作用以及细胞生长信号通路的调节。此外，Ahsg还参与炎症细胞因子产生的调节，使其成为癌症炎症的潜在标志物。Ahsg与癌症进展之间的复杂相互作用凸显了其作为各种癌症诊断生物标志物和治疗靶点的潜力。然而，需要进一步研究以充分阐明Ahsg在癌症中的作用机制，并探索其在癌症诊断、预后和治疗中的临床意义。
