Zuo Zhuo, Wang Yaxing, Fang Yanwei, Wang Zhe, Yang Zhouqi, Jia Bin, Sun Yulong
Key Laboratory for Space Biosciences & Biotechnology, School of Life Sciences, Institute of Special Environmental Biophysics, Research Center of Special Environmental Biomechanics and Medical Engineering, Engineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, Northwestern Polytechnical University, Xi'an 710072, China.
Int J Mol Sci. 2024 Dec 3;25(23):13005. doi: 10.3390/ijms252313005.
Psoriasis is a chronic inflammatory skin disease caused by abnormal activation and immune system disorder. Despite the availability of several treatments, they only provide temporary relief, and there is a critical need for more effective therapies to manage this condition. Electrostimulation has been widely used as a physical stimulus in treating various diseases, and recent studies have shown its potential in psoriasis treatment. In this review, we explore the direct and indirect effects of electrostimulation in treating psoriasis and their underlying mechanisms (the decreased secretion of inflammatory cytokines, the loss of cell-to-cell connections, and the cAMP signaling pathway). Our findings suggest that electrostimulation therapy may offer a promising approach to treating psoriasis and developing wearable devices for its management.
银屑病是一种由异常激活和免疫系统紊乱引起的慢性炎症性皮肤病。尽管有多种治疗方法，但它们只能提供暂时缓解，因此迫切需要更有效的疗法来控制这种疾病。电刺激已被广泛用作治疗各种疾病的物理刺激，最近的研究表明其在银屑病治疗中的潜力。在这篇综述中，我们探讨了电刺激在治疗银屑病中的直接和间接作用及其潜在机制（炎症细胞因子分泌减少、细胞间连接丧失和cAMP信号通路）。我们的研究结果表明，电刺激疗法可能为治疗银屑病和开发用于管理银屑病的可穿戴设备提供一种有前景的方法。
