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多巴胺:糖尿病视网膜病变发病机制中的新因素?

Dopamine: A New Player in the Pathogenesis of Diabetic Retinopathy?

作者信息

Ntikoudi Marianthi, Farmaki Theofano Myrto, Tziomalos Konstantinos

机构信息

First Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA Hospital, 54636 Thessaloniki, Greece.

出版信息

Int J Mol Sci. 2024 Dec 8;25(23):13196. doi: 10.3390/ijms252313196.

Abstract

Diabetic retinopathy (DR) is a leading cause of blindness. The pathogenesis of diabetic retinopathy is multifactorial and incompletely understood. Accordingly, treatment options are limited. Recent data suggest that dopamine might play a role in the development and progression of DR. In the present review, we discuss these data and comment on the potential role of dopamine modulation in the management of this devastating microvascular complication of diabetes mellitus.

摘要

糖尿病视网膜病变(DR)是导致失明的主要原因。糖尿病视网膜病变的发病机制是多因素的,尚未完全明确。因此,治疗选择有限。近期数据表明,多巴胺可能在糖尿病视网膜病变的发生和发展中起作用。在本综述中,我们讨论这些数据,并对多巴胺调节在糖尿病这一破坏性微血管并发症管理中的潜在作用进行评论。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caeb/11642112/98c4a31013fe/ijms-25-13196-g001.jpg

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