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多巴胺:糖尿病视网膜病变发病机制中的新因素?

Dopamine: A New Player in the Pathogenesis of Diabetic Retinopathy?

作者信息

Ntikoudi Marianthi, Farmaki Theofano Myrto, Tziomalos Konstantinos

机构信息

First Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA Hospital, 54636 Thessaloniki, Greece.

出版信息

Int J Mol Sci. 2024 Dec 8;25(23):13196. doi: 10.3390/ijms252313196.

DOI:10.3390/ijms252313196
PMID:39684908
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11642112/
Abstract

Diabetic retinopathy (DR) is a leading cause of blindness. The pathogenesis of diabetic retinopathy is multifactorial and incompletely understood. Accordingly, treatment options are limited. Recent data suggest that dopamine might play a role in the development and progression of DR. In the present review, we discuss these data and comment on the potential role of dopamine modulation in the management of this devastating microvascular complication of diabetes mellitus.

摘要

糖尿病视网膜病变(DR)是导致失明的主要原因。糖尿病视网膜病变的发病机制是多因素的,尚未完全明确。因此,治疗选择有限。近期数据表明,多巴胺可能在糖尿病视网膜病变的发生和发展中起作用。在本综述中,我们讨论这些数据,并对多巴胺调节在糖尿病这一破坏性微血管并发症管理中的潜在作用进行评论。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caeb/11642112/98c4a31013fe/ijms-25-13196-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caeb/11642112/98c4a31013fe/ijms-25-13196-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caeb/11642112/98c4a31013fe/ijms-25-13196-g001.jpg

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本文引用的文献

1
Diabetic retinopathy: New concepts of screening, monitoring, and interventions.糖尿病视网膜病变:筛查、监测和干预的新概念。
Surv Ophthalmol. 2024 Nov-Dec;69(6):882-892. doi: 10.1016/j.survophthal.2024.07.001. Epub 2024 Jul 2.
2
Recent advances in the treatment and delivery system of diabetic retinopathy.糖尿病视网膜病变的治疗和递药系统的最新进展。
Front Endocrinol (Lausanne). 2024 Feb 15;15:1347864. doi: 10.3389/fendo.2024.1347864. eCollection 2024.
3
Analysis of the Relationship Between Parkinson's Disease and Diabetic Retinopathy Based on Bioinformatics Methods.
基于生物信息学方法分析帕金森病与糖尿病视网膜病变的关系。
Mol Neurobiol. 2024 Sep;61(9):6395-6406. doi: 10.1007/s12035-024-03982-3. Epub 2024 Feb 3.
4
Research progress on the pathogenesis of diabetic retinopathy.糖尿病视网膜病变发病机制的研究进展。
BMC Ophthalmol. 2023 Sep 11;23(1):372. doi: 10.1186/s12886-023-03118-6.
5
Prevalence of Diabetic Retinopathy in the US in 2021.2021 年美国糖尿病视网膜病变的患病率。
JAMA Ophthalmol. 2023 Aug 1;141(8):747-754. doi: 10.1001/jamaophthalmol.2023.2289.
6
Diabetic rats with high levels of endogenous dopamine do not show retinal vascular pathology.内源性多巴胺水平高的糖尿病大鼠未表现出视网膜血管病变。
Front Neurosci. 2023 Mar 22;17:1125784. doi: 10.3389/fnins.2023.1125784. eCollection 2023.
7
Caffeine and the Risk of Diabetic Retinopathy in Type 2 Diabetes Mellitus: Findings from Clinical and Experimental Studies.咖啡因与 2 型糖尿病患者糖尿病视网膜病变风险的关系:临床和实验研究的结果。
Nutrients. 2023 Feb 25;15(5):1169. doi: 10.3390/nu15051169.
8
Dopamine ameliorates hyperglycemic memory-induced microvascular dysfunction in diabetic retinopathy.多巴胺可改善糖尿病视网膜病变中高血糖记忆引起的微血管功能障碍。
FASEB J. 2022 Dec;36(12):e22643. doi: 10.1096/fj.202200865R.
9
Activation of the GABA-alpha receptor by berberine rescues retinal ganglion cells to attenuate experimental diabetic retinopathy.小檗碱激活GABA-α受体可挽救视网膜神经节细胞,减轻实验性糖尿病视网膜病变。
Front Mol Neurosci. 2022 Aug 9;15:930599. doi: 10.3389/fnmol.2022.930599. eCollection 2022.
10
Mitochondrial Dynamics in the Metabolic Memory of Diabetic Retinopathy.线粒体动力学在糖尿病性视网膜病变的代谢记忆中的作用。
J Diabetes Res. 2022 Mar 31;2022:3555889. doi: 10.1155/2022/3555889. eCollection 2022.