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人类中耳植入物的见解:发现双稳态。

Insights into Human Middle Ear Implants: Uncovered Bistability.

作者信息

Zablotni Robert, Zając Grzegorz, Rusinek Rafal

机构信息

Department of Applied Mechanics, Mechanical Engineering Faculty, Lublin University of Technology, Nadbystrzycka 36, 20-618 Lublin, Poland.

Department of Power Engineering and Transportation, Faculty of Production Engineering, University of Life Sciences in Lublin, Głeboka 28, 20-612 Lublin, Poland.

出版信息

Materials (Basel). 2024 Nov 23;17(23):5730. doi: 10.3390/ma17235730.

DOI:10.3390/ma17235730
PMID:39685166
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11642658/
Abstract

This study delves into the intricate mechanics of human middle ear implants by examining a lumped parameter model with five degrees of freedom to estimate sound transfer. The ASTM standard, recognized globally as a benchmark, served as a reference for analysis, ensuring test accuracy and providing a comprehensive evaluation framework. To assess the implant's usability, numerical simulations were conducted and compared against both the ASTM standard and the experimental results obtained from temporal bone studies. This investigation uncovered the bistability of periodic responses induced by the implant, prompting an analysis of the bistability in periodic solutions and the creation of basins of attraction for various initial conditions. The discovery of new solutions underscores this study's significance in the operation and reliability of implants. Consequently, this research not only enhances the theoretical comprehension of the system, but also holds promise for practical applications in the design and optimization of middle ear implants that transfer energy to the stapes and the cochlea.

摘要

本研究通过检查一个具有五个自由度的集总参数模型来深入探究人类中耳植入物的复杂力学原理,以估计声音传递。被全球公认为基准的ASTM标准用作分析参考,确保测试准确性并提供全面的评估框架。为评估植入物的可用性,进行了数值模拟,并与ASTM标准以及从颞骨研究中获得的实验结果进行比较。该调查发现了由植入物引起的周期性响应的双稳性,促使对周期解中的双稳性进行分析,并为各种初始条件创建吸引域。新解的发现突出了本研究在植入物操作和可靠性方面的重要性。因此,这项研究不仅增强了对该系统的理论理解,而且在将能量传递到镫骨和耳蜗的中耳植入物的设计和优化的实际应用中也有前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a82/11642658/459c2c915dd7/materials-17-05730-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a82/11642658/b7092183e576/materials-17-05730-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a82/11642658/b8d42cdc3e13/materials-17-05730-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a82/11642658/8e6d651726a2/materials-17-05730-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a82/11642658/121e99ed5008/materials-17-05730-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a82/11642658/e26d9a2483f3/materials-17-05730-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a82/11642658/459c2c915dd7/materials-17-05730-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a82/11642658/b7092183e576/materials-17-05730-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a82/11642658/b8d42cdc3e13/materials-17-05730-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a82/11642658/8e6d651726a2/materials-17-05730-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a82/11642658/121e99ed5008/materials-17-05730-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a82/11642658/e26d9a2483f3/materials-17-05730-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a82/11642658/459c2c915dd7/materials-17-05730-g006.jpg

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本文引用的文献

1
Middle Ear Active Implant Indications, Comparative Audiometric Results from Different Approaches, and Coupling with the Vibrant Soundbridge: A Single Center Experience over More Than 20 Years.中耳主动植入的适应症、不同方法的比较听力测试结果以及与振动声桥的耦合:一个中心20多年的经验
Audiol Res. 2024 Aug 21;14(4):721-735. doi: 10.3390/audiolres14040061.
2
Implantable hearing devices in clinical practice. Systematic review and consensus statements.临床应用中的可植入式听力设备。系统评价和共识声明。
Acta Otorhinolaryngol Ital. 2024 Feb;44(1):52-67. doi: 10.14639/0392-100X-N2651. Epub 2023 Dec 29.
3
Autosomal Dominant Non-Syndromic Hearing Loss (DFNA): A Comprehensive Narrative Review.
常染色体显性非综合征性听力损失(DFNA):一篇全面的叙述性综述
Biomedicines. 2023 Jun 1;11(6):1616. doi: 10.3390/biomedicines11061616.
4
The onset of nonlinear growth of middle-ear responses to high intensity sounds.中耳对高强度声音响应的非线性增长的开始。
Hear Res. 2021 Jun;405:108242. doi: 10.1016/j.heares.2021.108242. Epub 2021 Apr 9.
5
[Laser Doppler vibrometric measurements on human temporal bones].[对人类颞骨的激光多普勒振动测量]
HNO. 2021 Jun;69(6):491-500. doi: 10.1007/s00106-021-00995-5. Epub 2021 Feb 10.
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Biomechanics of the Human Middle Ear with Viscoelasticity of the Maxwell and the Kelvin-Voigt Type and Relaxation Effect.具有麦克斯韦和开尔文-伏伊特型粘弹性及松弛效应的人中耳生物力学
Materials (Basel). 2020 Aug 27;13(17):3779. doi: 10.3390/ma13173779.
7
Mechanical Energy Dissipation Through the Ossicular Chain and Inner Ear Using Laser Doppler Vibrometer Measurement of Round Window Velocity.通过测量圆窗速度的激光多普勒振动计研究听骨链和内耳的机械能耗散。
Otol Neurotol. 2020 Mar;41(3):e387-e391. doi: 10.1097/MAO.0000000000002509.
8
Average middle ear frequency response curves with preservation of curve morphology characteristics.具有曲线形态特征保留的平均中耳频率响应曲线。
Hear Res. 2018 Jun;363:39-48. doi: 10.1016/j.heares.2018.02.005. Epub 2018 Feb 24.
9
A comparative study of MED-EL FMT attachment to the long process of the incus in intact middle ears and its attachment to disarticulated stapes head.MED-EL FMT在完整中耳中与砧骨长突的附着情况及其与脱位镫骨头附着情况的对比研究。
Hear Res. 2017 Sep;353:97-103. doi: 10.1016/j.heares.2017.06.006. Epub 2017 Jun 23.
10
Stapes displacement and intracochlear pressure in response to very high level, low frequency sounds.镫骨移位及耳蜗内压力对极高频、低频声音的反应。
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