Singh Vandana, Patil Ranjitkumar, Singh Subash, Tripathi Anurag, Khanna Vikram, Ali Wahid
Department of Oral Medicine and Radiology, Faculty of Dental Sciences, KGMU, Lucknow, Uttar Pradesh, India.
Department of Pedodontics and Preventive Dentistry, BBD CODS, Lucknow, Uttar Pradesh, India.
Natl J Maxillofac Surg. 2021 May-Aug;12(2):188-192. doi: 10.4103/njms.NJMS_268_20. Epub 2021 Jul 15.
Lipids are one of the major constituents of the cell. Variations in the serum lipids have been considered a cofactor of carcinogenesis, as lipids play a crucial role in cell integrity. Saliva is an ultrafiltrate of plasma and correlates with the serum, which may be used as an alternate method of serum lipid level estimation. The study was conducted to find any correlation between serum and salivary lipid levels and to evaluate the changes in serum and salivary lipid levels in oral precancer and cancer patients.
This study aimed to evaluate the changes in serum and salivary lipid levels in oral precancer and cancer patients and to correlate salivary lipid levels with serum lipid levels.
The study was an study conducted on randomly selected 129 patients with oral cancer and oral precancer. The selected subjects were divided into four groups as Group 1 - healthy control, Group 2 - oral submucous fibrosis, Group 3 - leukoplakia, and Group 4 - oral cancer. Serum and salivary lipid levels were estimated biochemically and statistically analyzed for any correlation with oral precancer and cancer.
Lipid level estimation showed no statistically significant difference on comparison of intergroup serum and saliva total cholesterol level and high-density lipoproteins among all four groups, whereas intergroup comparison of serum and saliva triglycerides (TG) levels among the four groups showed a statistically significant difference in saliva TG level. The correlation of serum and salivary lipid levels showed a significant positive correlation.
In the present study association between serum/salivary lipid levels and oral precancer and oral cancer could not be established. A positive association was there in serum and salivary lipids hence salivary lipid levels may be used as a noninvasive technique for serum lipid level estimation.
脂质是细胞的主要成分之一。血清脂质的变化被认为是致癌作用的一个辅助因素，因为脂质在细胞完整性中起着至关重要的作用。唾液是血浆的超滤液，与血清相关，可作为估计血清脂质水平的替代方法。本研究旨在发现血清和唾液脂质水平之间的任何相关性，并评估口腔癌前病变和癌症患者血清和唾液脂质水平的变化。
本研究旨在评估口腔癌前病变和癌症患者血清和唾液脂质水平的变化，并将唾液脂质水平与血清脂质水平进行关联。
本研究是一项对随机选择的129例口腔癌和口腔癌前病变患者进行的研究。所选受试者分为四组：第1组 - 健康对照，第2组 - 口腔黏膜下纤维化，第3组 - 白斑，第4组 - 口腔癌。对血清和唾液脂质水平进行生化测定，并进行统计分析以确定与口腔癌前病变和癌症的任何相关性。
脂质水平测定显示，在所有四组中，组间血清和唾液总胆固醇水平以及高密度脂蛋白的比较无统计学显著差异，而四组间血清和唾液甘油三酯（TG）水平的组间比较显示唾液TG水平有统计学显著差异。血清和唾液脂质水平的相关性显示出显著的正相关。
在本研究中，血清/唾液脂质水平与口腔癌前病变和口腔癌之间未建立关联。血清和唾液脂质之间存在正相关，因此唾液脂质水平可作为估计血清脂质水平的非侵入性技术。
