Almorín-Fernández-Vigo Ignacio, Pagán Carrasco Silvia, Sánchez-Guillén Inés, Fernández-Vigo José Ignacio, Macarro-Merino Ana, Kudsieh Bachar, Fernández-Vigo José Ángel
Centro Internacional de Oftalmología Avanzada, 06011 Badajoz, Spain.
Department of Ophthalmology, Hospital Universitario Rafael Mendez, 30817 Lorca, Spain.
J Clin Med. 2024 Nov 25;13(23):7125. doi: 10.3390/jcm13237125.
: To determine the impact of corneal and biometry parameters on the normative root mean square (RMS) values of corneal aberrations measured at a 6 mm diameter. : The RMS values for corneal aberrations (anterior, posterior, and total) were measured along with corneal parameters using Scheimpflug tomography on 770 normal subjects. The biometric parameters were measured with an optical biometer. A multiple linear regression model was used to assess the effect of these parameters on the RMS values for corneal aberrations. : The mean RMS values for low-order (LOAs) and high-order 6 mm aberrations (HOAs) were 1.883 ± 0.797 µm and 0.484 ± 0.173 µm, respectively, and for the anterior and posterior cornea, the values were 0.775 ± 0.166 µm and 0.189 ± 0.036 µm, respectively. For the anterior cornea, the main predictors of the RMS LOAs (R = 69.8%) were anterior corneal astigmatism (ACA) and anterior corneal elevation (Ele F) on the apex (both < 0.0001) and for the RMS HOAs (R = 33.3%) the main predictors were age, ACA, and Ele F on the thinnest point (all < 0.0001). For the posterior cornea, considering only the posterior corneal variables, the main predictors of the RMS LOAs (R = 63.4%) were posterior corneal astigmatism and posterior corneal elevation (Ele B) on the thinnest point and apex (all < 0.0001) and for the RMS HOAs (R = 46%) the main predictors were the mean posterior keratometry and Ele B on the thinnest point and apex (all < 0.0001). : Normative data of RMS values for corneal aberrations measured over 6 mm are influenced by age and several corneal parameters, which should be considered when evaluating the diagnostic ability of the RMS values.
: 确定角膜和生物测量参数对在6毫米直径下测量的角膜像差标准均方根（RMS）值的影响。: 使用Scheimpflug断层扫描技术，对770名正常受试者的角膜像差（前表面、后表面和总像差）的RMS值以及角膜参数进行了测量。生物测量参数使用光学生物测量仪进行测量。采用多元线性回归模型来评估这些参数对角膜像差RMS值的影响。: 低阶像差（LOAs）和高阶6毫米像差（HOAs）的平均RMS值分别为1.883±0.797微米和0.484±0.173微米，前角膜和后角膜的相应值分别为0.775±0.166微米和0.189±0.036微米。对于前角膜，RMS低阶像差（R = 69.8%）的主要预测因素是前角膜散光（ACA）和顶点处的前角膜高度（Ele F）（均P < 0.0001），对于RMS高阶像差（R = 33.3%），主要预测因素是年龄、ACA以及最薄点处的Ele F（均P < 0.0001）。对于后角膜，仅考虑后角膜变量，RMS低阶像差（R = 63.4%）的主要预测因素是后角膜散光和最薄点及顶点处的后角膜高度（Ele B）（均P < 0.0001），对于RMS高阶像差（R = 46%），主要预测因素是平均后角膜曲率以及最薄点和顶点处的Ele B（均P < 0.0001）。: 6毫米范围内测量的角膜像差RMS值的标准数据受年龄和多个角膜参数影响，在评估RMS值的诊断能力时应予以考虑。
