Stabile Guglielmo, Doria Alessandra, Bruno Matteo, D'Indinosante Marco, Gallotta Valerio, Fanfani Francesco, Scambia Giovanni, Restaino Stefano, Vizzielli Giuseppe, Carlucci Stefania, Nappi Luigi
Department of Medical and Surgical Sciences, Institute of Obstetrics and Gynecology, University of Foggia, 71121 Foggia, Italy.
UOC Ginecologia Oncologica, Dipartimento per le Scienze della Salute della Donna e del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy.
J Clin Med. 2024 Nov 25;13(23):7135. doi: 10.3390/jcm13237135.
: Endometrial cancer is currently the sixth most frequent cancer in women, and scientific research is focusing on the search for particular features of the endometrium that may explain a further predisposition to the onset of endometrial cancer, aimed at improving knowledge of the pathogenetic factors of this disease. The aim of our review is to analyze in detail the results of the literature on the endometrial microbiota in patients with endometrial cancer and to investigate its role. : We performed our research on the Pubmed, Web of Science, and Scopus databases. We searched up to December 2023 and considered manuscripts published from 2000. Only articles in English were included in the search. We excluded studies in which the endometrial microbiota were collected through the vagina or cervical canal. : We included in our review a total of five manuscripts at the end of the screening process, and the total number of patients involved was 190. Four studies considered only post-menopausal patients, while one study considered both pre- and post-menopausal patients. In all studies, the microbiota analysis was derived from a post-hysterectomy biopsy. From our review, it emerged that Bacteroidetes, Actinobacteria, Firmicutes, and Proteobacteria are the most represented bacteria in patients with endometrial cancer. These are both Gram-positive and Gram-negative, but predominantly anaerobic bacteria. : The reduced microbial diversity and the presence of specific bacteria is often associated with endometrial cancer. Further work on larger population samples, and on healthy women and those affected by endometrial carcinoma, is needed to understand how the endometrial microbiota changes and influences the development of the tumor and whether intervening in the changes in the microbiota will have a therapeutic impact on endometrial carcinoma.
子宫内膜癌是目前女性中第六大常见癌症，科学研究聚焦于寻找子宫内膜的特定特征，这些特征可能解释子宫内膜癌发病的进一步易感性，旨在增进对该疾病致病因素的了解。我们综述的目的是详细分析关于子宫内膜癌患者子宫内膜微生物群的文献结果，并研究其作用。
我们在PubMed、科学网和Scopus数据库上进行了研究。我们搜索截至2023年12月的文献，并纳入2000年以来发表的手稿。搜索仅包括英文文章。我们排除了通过阴道或宫颈管收集子宫内膜微生物群的研究。
在筛选过程结束时，我们的综述共纳入了五篇手稿，涉及的患者总数为190例。四项研究仅考虑绝经后患者，而一项研究同时考虑了绝经前和绝经后患者。在所有研究中，微生物群分析均来自子宫切除术后的活检。从我们的综述中可以看出，拟杆菌门、放线菌门、厚壁菌门和变形菌门是子宫内膜癌患者中最具代表性的细菌。这些细菌既有革兰氏阳性菌，也有革兰氏阴性菌，但主要是厌氧菌。
微生物多样性降低和特定细菌的存在通常与子宫内膜癌有关。需要对更大规模的人群样本、健康女性以及受子宫内膜癌影响的女性进行进一步研究，以了解子宫内膜微生物群如何变化并影响肿瘤的发展，以及干预微生物群的变化是否会对子宫内膜癌产生治疗作用。
