Gaita Laura, Timar Bogdan, Lazar Sandra, Popescu Simona, Albai Oana, Braha Adina, Timar Romulus
Second Department of Internal Medicine, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
"Pius Brînzeu" Emergency County Hospital, 300723 Timisoara, Romania.
J Clin Med. 2024 Dec 1;13(23):7306. doi: 10.3390/jcm13237306.
Anemia is a prevalent comorbidity of diabetes, and although various mechanisms have been shown to link these two conditions, their interaction has not been sufficiently explored. Our cross-sectional, non-interventional study aimed to evaluate the prevalence of anemia and its subtypes, as well as their interactions, in patients with type 2 diabetes (T2D). A total of 227 patients previously diagnosed with T2D were enrolled. These patients were assessed regarding their medical history and the evolution of their diabetes, and were screened for anemia. Anemia was encountered in 32.6% of the 227 hospitalized patients previously diagnosed with T2D enrolled in this study. Its presence was associated with a higher prevalence of complications and comorbidities, such as chronic kidney disease (CKD), retinopathy, and atrial fibrillation. The most common types of anemia observed were those associated with CKD, other chronic conditions, and iron deficiency. A moderate, positive correlation (r = 0.307; < 0.0001) has been observed between estimated glomerular filtration rate (eGFR) and hemoglobin, and a moderate, negative correlation has been observed between age and hemoglobin (r = -0.351; < 0.0001), with the results also analyzed using multiple regression and ROC curve analysis. Additionally, a weak, positive, yet statistically significant correlation was observed between glycemic values and hemoglobin levels, which requires further research. Anemia is frequently encountered in patients with T2D, especially in those with increased age, decreased eGFR, and additional chronic degenerative complications or other comorbidities; thus, a systematic screening for an early diagnosis and interdisciplinary management is recommended for improved outcomes related to morbidity, mortality, and quality of life.
贫血是糖尿病常见的合并症，尽管已有多种机制表明这两种疾病存在关联，但它们之间的相互作用尚未得到充分研究。我们的横断面非干预性研究旨在评估2型糖尿病（T2D）患者中贫血及其亚型的患病率，以及它们之间的相互作用。共纳入227例先前诊断为T2D的患者。对这些患者的病史和糖尿病病情进展进行了评估，并进行了贫血筛查。在本研究纳入的227例先前诊断为T2D的住院患者中，32.6%的患者存在贫血。贫血的存在与慢性肾病（CKD）、视网膜病变和心房颤动等并发症和合并症的较高患病率相关。观察到的最常见贫血类型是与CKD、其他慢性疾病和缺铁相关的贫血。估计肾小球滤过率（eGFR）与血红蛋白之间观察到中度正相关（r = 0.307；< 0.0001），年龄与血红蛋白之间观察到中度负相关（r = -0.351；< 0.0001），结果还使用多元回归和ROC曲线分析进行了分析。此外，血糖值与血红蛋白水平之间观察到弱的正相关且具有统计学意义，这需要进一步研究。T2D患者中经常出现贫血，尤其是年龄增加、eGFR降低以及有其他慢性退行性并发症或其他合并症的患者；因此，建议进行系统筛查以早期诊断并进行跨学科管理，以改善与发病率、死亡率和生活质量相关的结局。
