Pourmasoumi Parvin, Banihashemian Seyed Abdolvahab, Zamani Farshid, Rasouli-Nia Aghdass, Mehrabani Davood, Karimi-Busheri Feridoun
Department of Biomedical Engineering, Central Tehran Branch, Islamic Azad University, Tehran 19395-1495, Iran.
Stem Cells Research Center, Tissue Engineering and Regenerative Medicine Institute, Central Tehran Branch, Islamic Azad University, Tehran 14778-93780, Iran.
J Clin Med. 2024 Dec 6;13(23):7449. doi: 10.3390/jcm13237449.
Glioblastomas are highly invasive brain tumors among perilous diseases. They are characterized by their fast proliferation and delayed detection that render them a significant focal point for medical research endeavors within the realm of cancer. Among glioblastomas, (GBM) is the most aggressive and prevalent malignant brain tumor. For this, nanomaterials such as metallic and lipid nanoparticles and quantum dots have been acknowledged as efficient carriers. These nano-materials traverse the blood-brain barrier (BBB) and integrate and reach the necessary regions for neuro-oncology imaging and treatment purposes. This paper provides a thorough analysis on nanoparticles used in the diagnosis and treatment of brain tumors, especially for GBM.
胶质母细胞瘤是危险疾病中具有高度侵袭性的脑肿瘤。它们的特点是增殖迅速且检测延迟，这使其成为癌症领域医学研究工作的重要焦点。在胶质母细胞瘤中，胶质母细胞瘤（GBM）是最具侵袭性和最常见的恶性脑肿瘤。为此，金属和脂质纳米颗粒以及量子点等纳米材料已被公认为是有效的载体。这些纳米材料能够穿过血脑屏障（BBB），并整合并到达神经肿瘤成像和治疗所需的区域。本文对用于脑肿瘤诊断和治疗的纳米颗粒进行了全面分析，特别是针对胶质母细胞瘤。
