Kochanowski B A, Sherman A R
J Nutr. 1985 Feb;115(2):279-87. doi: 10.1093/jn/115.2.279.
Effects of iron deficiency and repletion pre- and postweaning on cell growth in young rats were studied. Pregnant dams were fed 6 or 250 ppm iron. On d 2 of lactation, half of the dams in each group were fed the opposite diet. On d 17, cell growth in the crossed-over groups was similar to controls showing that cellular development is impaired only when the iron deficiency is present during gestation and lactation. In a second experiment pup littermates of dams fed 6 (D), 12 (M) and 250 (C) ppm iron were weaned to either the same diet as fed to their dams DD, MM or CC; repleted with iron DC, MC; or fed the deficient diet CD until 42 d of age. After dietary iron repletion, cell numbers in thymus (DC and MC) and liver (DC) were greater than those of deficient littermates, but were less than those of controls (CC). Iron repletion postweaning reduced the cardiac hypertrophy (DC vs. DD and MC vs. MM) and increased splenic cell number compared to unrepleted deficient littermates (DC vs. DD). Thus, the severity and reversibility of impaired cellular growth is dependent on the timing and severity of the deficiency and the organ affected.
研究了断奶前后缺铁及补铁对幼鼠细胞生长的影响。给怀孕母鼠喂食含铁量为6 ppm或250 ppm的饲料。在哺乳期第2天，每组中一半的母鼠改喂另一种饲料。在第17天，交叉组的细胞生长与对照组相似，这表明只有在妊娠和哺乳期出现缺铁时，细胞发育才会受到损害。在第二个实验中，将喂食含铁量为6 ppm（D组）、12 ppm（M组）和250 ppm（C组）饲料的母鼠所生的同窝幼崽断奶后，分别喂食与母鼠相同的饲料（DD、MM或CC）；补充铁（DC、MC）；或喂食缺铁饲料（CD）直至42日龄。饮食补铁后，胸腺（DC和MC组）和肝脏（DC组）中的细胞数量高于缺铁同窝幼崽，但低于对照组（CC组）。与未补铁的缺铁同窝幼崽相比，断奶后补铁可减轻心脏肥大（DC组与DD组对比，MC组与MM组对比）并增加脾细胞数量（DC组与DD组对比）。因此，细胞生长受损的严重程度和可逆性取决于缺铁的时间和严重程度以及受影响的器官。
