铁螯合对炎性关节疾病的影响。
Effect of iron chelation on inflammatory joint disease.
作者信息
Andrews F J, Morris C J, Kondratowicz G, Blake D R
出版信息
Ann Rheum Dis. 1987 Apr;46(4):327-33. doi: 10.1136/ard.46.4.327.
Abstract
Mild iron deficiency induced by treatment with the iron chelator desferrioxamine reduced the incidence and severity of joint inflammation associated with adjuvant disease in rats but did not alter the local primary inflammatory response or the systemic sequelae. Both rats treated with desferrioxamine and control rats showed increased levels of alpha 1 acid glycoprotein, characteristic pathological changes in the liver and inguinal lymph nodes, and the primary inflammatory response at the site of injection. Histology, microfocal radiography, and gross assessment of the joints, however, showed a suppression or reduction in soft tissue swelling and bone erosion in the rats treated with desferrioxamine. This is a novel observation suggesting an apparently selective influence of iron on joint mediated inflammation.
摘要
用铁螯合剂去铁胺治疗诱导的轻度缺铁降低了大鼠佐剂性疾病相关关节炎症的发生率和严重程度，但未改变局部原发性炎症反应或全身后遗症。接受去铁胺治疗的大鼠和对照大鼠均显示α1酸性糖蛋白水平升高、肝脏和腹股沟淋巴结出现特征性病理变化以及注射部位的原发性炎症反应。然而，组织学、微焦点射线照相术以及对关节的大体评估显示，接受去铁胺治疗的大鼠软组织肿胀和骨质侵蚀受到抑制或减轻。这是一项新的观察结果，表明铁对关节介导的炎症具有明显的选择性影响。
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