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超声与弹性成像在肝脂肪变性诊断中的应用:传统机器学习与深度学习的评估

Ultrasound Versus Elastography in the Diagnosis of Hepatic Steatosis: Evaluation of Traditional Machine Learning Versus Deep Learning.

作者信息

Marques Rodrigo, Santos Jaime, André Alexandra, Silva José

机构信息

Faculdade de Ciências e Tecnologias, Department of Physics, University of Coimbra, Rua Larga, 3004-516 Coimbra, Portugal.

Department of Electrical and Computers Engineering, CEMMPRE-ARISE, University of Coimbra, Polo II, Rua Sílvio Lima, 3030-970 Coimbra, Portugal.

出版信息

Sensors (Basel). 2024 Nov 27;24(23):7568. doi: 10.3390/s24237568.

DOI:10.3390/s24237568
PMID:39686106
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11644170/
Abstract

The prevalence of fatty liver disease is on the rise, posing a significant global health concern. If left untreated, it can progress into more serious liver diseases. Therefore, accurately diagnosing the condition at an early stage is essential for more effective intervention and management. This study uses images acquired via ultrasound and elastography to classify liver steatosis using classical machine learning classifiers, including random forest and support vector machine, as well as deep learning architectures, such as ResNet50V2 and DenseNet-201. The neural network demonstrated the most optimal performance, achieving an F1 score of 99.5% on the ultrasound dataset, 99.2% on the elastography dataset, and 98.9% on the mixed dataset. The results from the deep learning approach are comparable to those of machine learning, despite objectively not achieving the highest results. This research offers valuable insights into the domain of medical image classification and advocates the integration of advanced machine learning and deep learning technologies in diagnosing steatosis.

摘要

脂肪肝疾病的患病率正在上升,这成为一个重大的全球健康问题。如果不加以治疗,它可能会发展成更严重的肝脏疾病。因此,早期准确诊断病情对于更有效的干预和管理至关重要。本研究使用通过超声和弹性成像获取的图像,利用经典机器学习分类器(包括随机森林和支持向量机)以及深度学习架构(如ResNet50V2和DenseNet - 201)对肝脏脂肪变性进行分类。神经网络表现出最优化的性能,在超声数据集上的F1分数达到99.5%,在弹性成像数据集上为99.2%,在混合数据集上为98.9%。尽管客观上深度学习方法未取得最高结果,但其结果与机器学习的结果相当。这项研究为医学图像分类领域提供了有价值的见解,并提倡在诊断脂肪变性中整合先进的机器学习和深度学习技术。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0aff/11644170/05cd4edf5757/sensors-24-07568-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0aff/11644170/20c172051ec0/sensors-24-07568-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0aff/11644170/a38aef4584fc/sensors-24-07568-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0aff/11644170/eb0c564d2c4b/sensors-24-07568-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0aff/11644170/74e10f33486a/sensors-24-07568-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0aff/11644170/96fc3960a565/sensors-24-07568-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0aff/11644170/05cd4edf5757/sensors-24-07568-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0aff/11644170/20c172051ec0/sensors-24-07568-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0aff/11644170/a38aef4584fc/sensors-24-07568-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0aff/11644170/eb0c564d2c4b/sensors-24-07568-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0aff/11644170/74e10f33486a/sensors-24-07568-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0aff/11644170/96fc3960a565/sensors-24-07568-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0aff/11644170/05cd4edf5757/sensors-24-07568-g008.jpg

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本文引用的文献

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Performance of two-dimensional shear wave elastography and transient elastography compared to liver biopsy for staging of liver fibrosis.二维剪切波弹性成像和瞬时弹性成像与肝活检在肝纤维化分期中的比较。
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The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review.非酒精性脂肪性肝病(NAFLD)和非酒精性脂肪性肝炎(NASH)的全球流行病学:系统评价。
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Accurate and generalizable quantitative scoring of liver steatosis from ultrasound images scalable deep learning.
基于可扩展深度学习的超声图像肝脂肪变性准确且可推广的定量评分
World J Gastroenterol. 2022 Jun 14;28(22):2494-2508. doi: 10.3748/wjg.v28.i22.2494.
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Diagnosis of steatohepatitis and fibrosis in biopsy-proven nonalcoholic fatty liver diseases: including two-dimension real-time shear wave elastography and noninvasive fibrotic biomarker scores.经活检证实的非酒精性脂肪性肝病中脂肪性肝炎和肝纤维化的诊断:包括二维实时剪切波弹性成像和无创纤维化生物标志物评分
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Point Shear Wave Elastography by ElastPQ for Fibrosis Screening in Patients with NAFLD: A Prospective, Multicenter Comparison to Vibration-Controlled Elastography.基于 ElastPQ 的剪切波弹性成像技术对非酒精性脂肪性肝病患者纤维化的筛查:一项与受控振动弹性成像的前瞻性多中心比较。
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Transfer learning with pre-trained deep convolutional neural networks for the automatic assessment of liver steatosis in ultrasound images.基于预训练深度卷积神经网络的迁移学习在超声图像中自动评估肝脂肪变性。
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