Wang Wen, Ye Xiangming, Wang Sisi
Department of Preventive Treatment Center, Quzhou Hospital of Traditional Chinese Medicine, Quzhou, Zhejiang, People's Republic of China.
Department of Rehabilitation Medicine, Center for Rehabilitation Medicine, Rehabilitation & Sports Medicine Research Institute of Zhejiang Province, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, People's Republic of China.
Medicine (Baltimore). 2024 Dec 13;103(50):e37108. doi: 10.1097/MD.0000000000037108.
Vitamins are essential nutrients that play an indispensable role in maintaining the vital functions of the human body. A growing number of studies have shown a link between vitamins and cancer. However, there is no systematic review and bibliometric analysis in this field. This study aims to summarize the hotspots and emerging research topics in this field of vitamins and cancer research.
Articles on the topic of vitamins and cancer published between 2003 and 2022 were retrieved from the Web of Science core collection database (WOSCC) on May 1, 2023. Subsequently, we conducted VOSviewer and CiteSpace to examine the annual output distribution, countries/regions, institutions, journals, authors, co-cited references, and keywords.
A total of 3166 publications were extracted using a timespan of 2003 to 2022. The number of publications has grown rapidly over the past 20 years. Most publications were from the United States; Harvard University was the most active institutions; Giovannucci stood out among authors with the highest number of publications, citations and H-index; Cancer Epidem Biomar published the most papers in this field; the highest cited reference was published in Nat Rev Cancer, authored by Feldman in 2014. Breast cancer was the most common type of cancer, while vitamin D was a research hotspot in this field. Oxidative stress may be the primary anticancer mechanism of vitamins, while also involving epithelial-mesenchymal transition, apoptosis, polymorphism, and calcium metabolism. "nanoparticle" may be the new focus of attention in the next few years.
This study presented an overview of the major research directions of vitamins and cancer by bibliometric methods over the past 2 decades. The results could reveal the research trends and the hotspots in the field and provide helpful information for clinical treatments of cancer.
维生素是维持人体重要功能不可或缺的必需营养素。越来越多的研究表明维生素与癌症之间存在联系。然而，该领域尚无系统综述和文献计量分析。本研究旨在总结维生素与癌症研究领域的热点和新兴研究主题。
于2023年5月1日从科学网核心合集数据库（WOSCC）中检索2003年至2022年间发表的关于维生素与癌症主题的文章。随后，我们使用VOSviewer和CiteSpace来研究年产出分布、国家/地区、机构、期刊、作者、共被引参考文献和关键词。
使用2003年至2022年的时间跨度共提取了3166篇出版物。在过去20年中，出版物数量迅速增长。大多数出版物来自美国；哈佛大学是最活跃的机构；乔瓦努奇在发表文章数量、被引次数和H指数最高的作者中脱颖而出；《癌症流行病学与生物标志物》在该领域发表的论文最多；被引次数最高的参考文献发表于2014年的《自然综述：癌症》，作者是费尔德曼。乳腺癌是最常见的癌症类型，而维生素D是该领域的研究热点。氧化应激可能是维生素的主要抗癌机制，同时还涉及上皮-间质转化、细胞凋亡、多态性和钙代谢。“纳米颗粒”可能是未来几年新的关注焦点。
本研究通过文献计量方法概述了过去20年维生素与癌症的主要研究方向。结果可揭示该领域的研究趋势和热点，并为癌症的临床治疗提供有用信息。
