Yang Yanmeng, Wang Guangming, Tang Yanlong
Radiology Department of the First Affiliated Hosptial of Dali University, Dali, Yunnan, China.
Clinical Medical Laboratory Centre, The First Affiliated Hospital of Dali University, Dali, Yunnan, China.
Medicine (Baltimore). 2024 Dec 13;103(50):e40728. doi: 10.1097/MD.0000000000040728.
Rapid diagnosis of acute ischemic stroke (AIS) remains challenging, and reliable biomarkers are needed. MicroRNAs (miRNAs) are endogenous small noncoding regulatory RNA molecules present in the serum, plasma, and saliva. miRNAs are considered to be sensitive biomarkers of tissue damage because of their high stability and relative tissue specificity. The aim of this systematic review was to assess the correlation between miRNAs and infarct volume in patients with AIS, to provide a basis for predicting ischemic stroke onset and improving prognosis in the clinic, among others.
From the search of published Chinese and English literature in PubMed, Cochrane Library, CNKI, VIP, and Wanfang databases up to July 1, 2023, we performed a descriptive summary of the included studies. And use of 12 quality evaluation items and Cochrane Risk of Bias tool to assess the quality of included studies.
This systematic review included 17 studies with articles involving 1443 cases were included in the data extraction for a total of 18 miRNA indicators. Among them, 9 indicators were positively associated with infarct volume in patients with AIS, including endothelial microvesicles-miR-155, miR-146b, miR-181c, miR-182, miR-34a, miR-92a, miR-122-5p, miR-451a, and miR-409-3P.
This study shows that miRNA can be used as a biomarker for AIS, reflecting the severity of neurological deficits in this patient and providing a basis for clinical judgement of the patient's prognosis.
急性缺血性卒中（AIS）的快速诊断仍然具有挑战性，因此需要可靠的生物标志物。微小RNA（miRNA）是存在于血清、血浆和唾液中的内源性小非编码调节RNA分子。由于其高稳定性和相对的组织特异性，miRNA被认为是组织损伤的敏感生物标志物。本系统评价的目的是评估AIS患者中miRNA与梗死体积之间的相关性，为临床预测缺血性卒中的发生及改善预后等提供依据。
通过检索截至2023年7月1日在PubMed、Cochrane图书馆、中国知网、维普和万方数据库中发表的中英文文献，我们对纳入的研究进行了描述性总结。并使用12项质量评价条目和Cochrane偏倚风险工具来评估纳入研究的质量。
本系统评价纳入17项研究，涉及1443例患者的文章被纳入数据提取，共18个miRNA指标。其中，9个指标与AIS患者的梗死体积呈正相关，包括内皮微泡-miR-155、miR-146b、miR-181c、miR-182、miR-34a、miR-92a、miR-122-5p、miR-451a和miR-409-3P。
本研究表明，miRNA可作为AIS的生物标志物，反映该患者神经功能缺损的严重程度，为临床判断患者预后提供依据。
