Benny Benetta, Bains Anupama, Nalwa Aasma
Department of Dermatology and Venereology, All India Institute of Medical Sciences, Jodhpur, India.
Department of Pathology and Lab Medicine, All India Institute of Medical Sciences, Jodhpur, India.
Australas J Dermatol. 2025 Mar;66(2):105-106. doi: 10.1111/ajd.14403. Epub 2024 Dec 16.
Erosive vulvovaginal lichen planus is a severe form of Lichen planus (LP) that can result in chronic scarring if not treated. It can cause narrowing of the introitus, resulting in pain, itch, dyspareunia, dysuria, and recurrent urinary tract infections caused by retention of urine. Therefore, an effective and safer therapeutic approach is required. Here, we present a case of refractory erosive vulvovaginal LP, which showed remarkable response to oral tofacitinib, a Janus kinase 1 and 3 (JAK1/3) inhibitor, which was well tolerated.
糜烂性外阴阴道扁平苔藓是扁平苔藓（LP）的一种严重形式，若不治疗可导致慢性瘢痕形成。它可引起阴道口狭窄，导致疼痛、瘙痒、性交困难、排尿困难以及因尿液潴留引起的复发性尿路感染。因此，需要一种有效且更安全的治疗方法。在此，我们报告一例难治性糜烂性外阴阴道LP病例，该病例对口服托法替布（一种Janus激酶1和3（JAK1/3）抑制剂）表现出显著反应，且耐受性良好。
