Jang Nelly, Fischer Gayle
Department of Dermatology, Royal North Shore Hospital, St Leonards, New South Wales, Australia.
Australas J Dermatol. 2008 Nov;49(4):216-9. doi: 10.1111/j.1440-0960.2008.00472.x.
We report the successful treatment of severe long-standing erosive vulvovaginal lichen planus in four adult female patients using 2.5-7.5 mg of oral methotrexate once weekly in conjunction with topical clobetasol dipropionate 0.05% ointment and tacrolimus 0.03-0.10% ointment. All cases experienced improvement in symptoms and healing of lesions within 4-8 weeks. Methotrexate was well tolerated and no adverse events have been observed in any of the patients at follow up 4-6 months later.
我们报告了4例成年女性患者严重长期糜烂性外阴阴道扁平苔藓的成功治疗，方法是每周口服一次2.5 - 7.5毫克甲氨蝶呤，同时外用0.05%丙酸氯倍他索软膏和0.03 - 0.10%他克莫司软膏。所有病例在4 - 8周内症状均有改善，病变愈合。甲氨蝶呤耐受性良好，在4 - 6个月后的随访中，所有患者均未观察到不良事件。
