Li Xu, Li Hui, Wang Zihao, Wang Xianda, Zhang Jinlong, Bin Fengjiao, Chen Wei, Li Hongyang, Huo Dongmei, Xiao Dengbao
Institute of Advanced Structure Technology, Beijing Institute of Technology, Beijing, 100081, China.
Beijing University of Technology, Beijing, 100124, China.
Adv Sci (Weinh). 2025 Feb;12(6):e2412630. doi: 10.1002/advs.202412630. Epub 2024 Dec 16.
Efficient drug delivery is crucial for glaucoma patients. Flexible biomedical devices that enable sustained ocular drug delivery and can regulate the drug release rate according to physiological conditions are highly desirable for glaucoma treatments, addressing both low drug bioavailability and poor patient compliance from manual drug administration, and improving treatment outcomes. Inspired by the structure and reciprocating motion of fish dorsal fins, a drug-eluting contact lens based on deformable microstructures for non-invasive ocular surface drug delivery is developed. Liquid drugs are stored within the interstices of the deformable microstructural units, allowing for continuous drug release through diffusion upon contact with the ocular surface. Finite element analysis is utilized to study the intraocular drug transport dynamics of glaucoma and optimize the overall layout of the device. Microstructural units undergo deformation under loading, altering the interstitial spaces and modulating the drug release rate. This device can adaptively adjust its drug release rate based on changes in intraocular pressure (IOP) and can be proactively regulated in response to cyclic eye loads, accommodating elevated IOP caused by varying body postures and activities. As a flexible, non-invasive, highly dynamic, and adaptive drug delivery platform, it holds significant potential for future biomedical applications.
高效的药物递送对青光眼患者至关重要。对于青光眼治疗而言，能够实现持续眼部药物递送并可根据生理状况调节药物释放速率的柔性生物医学装置非常理想，它既能解决药物生物利用度低的问题，又能改善因手动给药导致的患者依从性差的状况，进而提高治疗效果。受鱼背鳍的结构和往复运动启发，开发了一种基于可变形微结构的用于非侵入性眼表药物递送的药物洗脱隐形眼镜。液体药物储存在可变形微结构单元的间隙中，与眼表接触时通过扩散实现药物持续释放。利用有限元分析研究青光眼的眼内药物传输动力学并优化装置的整体布局。微结构单元在加载时会发生变形，改变间隙空间并调节药物释放速率。该装置可根据眼内压（IOP）的变化自适应调整其药物释放速率，并可响应周期性眼部负荷进行主动调节，以适应因身体姿势和活动变化引起的IOP升高。作为一个灵活、非侵入性、高度动态且自适应的药物递送平台，它在未来生物医学应用中具有巨大潜力。
