Brookes G B
J R Soc Med. 1985 Jan;78(1):47-55. doi: 10.1177/014107688507800110.
During the last year patients presenting with progressive bilateral or sudden sensorineural deafness of unknown aetiology have been investigated for possible abnormal immune activity. Twenty-six cases are reported in which significantly raised circulating immune complexes were present, together with 2 cases of clinical autoimmune deafness where the complexes were normal. Thirty-six control subjects were also studied. Following a review of the clinical features, the pathogenesis of this new association with sensorineural deafness is discussed. In some cases the aetiology is probably autoimmune, and in others related to infection. In certain patients the deafness has been partly reversed by medical treatment with systemic steroids or plasma exchange. It is hypothesized that circulating immune complexes may reflect a previously unrecognized final common pathophysiological pathway in a variety of cochleovestibular disorders.
在过去一年中，对病因不明的进行性双侧或突发性感音神经性耳聋患者进行了调查，以确定其免疫活性是否异常。本文报告了26例循环免疫复合物显著升高的病例，以及2例临床自身免疫性耳聋但复合物正常的病例。还对36名对照受试者进行了研究。在回顾临床特征后，讨论了这种与感音神经性耳聋新关联的发病机制。在某些病例中，病因可能是自身免疫性的，而在其他病例中则与感染有关。在某些患者中，全身性类固醇或血浆置换治疗已部分逆转了耳聋。据推测，循环免疫复合物可能反映了各种耳蜗前庭疾病中以前未被认识的最终共同病理生理途径。
