Kanzaki J, Ouchi T
Arch Otorhinolaryngol. 1981;230(1):5-9. doi: 10.1007/BF00665374.
We have recognized in recent years that some cases with idiopathic bilateral sensorineural hearing loss which showed acute progression in either ear responded to steroid and that the improved hearing level could be maintained by longterm administration of steroid only. Forty cases of bilateral sensorineural hearing loss were selected for study. In most of these cases hearing deterioration of either ear was confirmed by audiometry. Eight of fifteen cases with marked improvement have been proved to respond to steroid treatment. These eight cases include three cases with syphilitic deafness and one case with aortitis syndrome. In four other cases the causes are still unknown, but could be due to autoimmune mechanisms. In four of 25 cases the immune complexes (IC) value was higher than normal and three among them responded to steroid. Since a high IC value has been reported in lupus nephritis, immunologic examinations are necessary for patients over 30 years of age with bilateral sensorineural hearing loss.
近年来我们已经认识到，一些特发性双侧感音神经性听力损失病例，其双耳中任何一耳呈急性进展，对类固醇有反应，且仅通过长期给予类固醇就能维持改善后的听力水平。选择了40例双侧感音神经性听力损失病例进行研究。在大多数这些病例中，通过听力测定证实了双耳中任何一耳的听力恶化。15例有明显改善的病例中，有8例已被证明对类固醇治疗有反应。这8例包括3例梅毒性耳聋和1例主动脉炎综合征。在其他4例中，病因仍不明，但可能是由于自身免疫机制。25例中有4例免疫复合物（IC）值高于正常，其中3例对类固醇有反应。由于狼疮性肾炎中曾报道有高IC值，因此对于30岁以上的双侧感音神经性听力损失患者，有必要进行免疫学检查。
