Sun Caizhi, Xie Yongpeng, Zhu Chenchen, Guo Lei, Xu Bowen, Qin Haidong, Li Xiaomin
Department of Emergency Medicine, Lianyungang Clinical College, Nanjing Medical University, Lianyungang, Jiangsu, China.
Department of Emergency Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
PeerJ. 2024 Dec 13;12:e18718. doi: 10.7717/peerj.18718. eCollection 2024.
Mrp 8/14 is abundantly secreted by activated neutrophils during infection and inflammation. However, its prognostic value in acute respiratory distress dyndrome (ARDS) induced by sepsis is poorly understood. Our aim was to investigate the relationship between serum Mrp 8/14 and the prognosis in sepsis-induced ARDS patients admitted to the intensive care unit (ICU).
Serum Mrp 8/14 concentrations were analyzed in 118 ARDS patients induced by sepsis included in the analytical study. Patients were enrolled upon admission to the ICU of Nanjing Hospital affiliated to Nanjing Medical University. The baseline information and clinical outcomes were obtained. Patients were divided into survivor group and non-survivor group according to whether they died during ICU hospitalization.
The serum Mrp 8/14 levels were significantly increased in the non-survivor group compared to the survivor group ( < 0.05). Logistic regression analysis showed that serum Mrp 8/14, albumin and APACHE II were the independent factors for predicting the prognosis of sepsis-induced ARDS during ICU hospitalization after adjustment. Additionally, the area under the receiver operating characteristic curve for Mrp 8/14 combined with albumin was associated with ICU mortality and was higher than that of Mrp 8/14, albumin, APACHE II and Mrp 8/14 combined with APACHE II (all < 0.05). A nomogram was constructed to predict ICU mortality and the c-indexes of predictive accuracy was 0.830 in the cohort ( < 0.05).
The serum Mrp 8/14 upon ICU admission in septic patients may be useful for predicting mortality in sepsis-induced ARDS patients during ICU hospitalization.
在感染和炎症期间，活化的中性粒细胞会大量分泌髓系相关蛋白8/14（Mrp 8/14）。然而，其在脓毒症诱导的急性呼吸窘迫综合征（ARDS）中的预后价值尚不清楚。我们的目的是研究脓毒症诱导的ARDS患者入住重症监护病房（ICU）时血清Mrp 8/14与预后之间的关系。
在纳入分析研究的118例脓毒症诱导的ARDS患者中分析血清Mrp 8/14浓度。患者在南京医科大学附属南京医院ICU入院时登记。获取基线信息和临床结局。根据患者在ICU住院期间是否死亡，将其分为存活组和非存活组。
与存活组相比，非存活组血清Mrp 8/14水平显著升高（<0.05）。Logistic回归分析显示，调整后血清Mrp 8/14、白蛋白和急性生理与慢性健康状况评分系统II（APACHE II）是预测ICU住院期间脓毒症诱导的ARDS预后的独立因素。此外，Mrp 8/14与白蛋白联合的受试者工作特征曲线下面积与ICU死亡率相关，且高于Mrp 8/14、白蛋白、APACHE II以及Mrp 8/14与APACHE II联合的曲线下面积（均<0.05）。构建了一个列线图来预测ICU死亡率，该队列中预测准确性的c指数为0.830（<0.05）。
脓毒症患者入住ICU时的血清Mrp 8/14可能有助于预测ICU住院期间脓毒症诱导的ARDS患者的死亡率。
