微小RNA在免疫系统对心力衰竭的炎症反应中的作用。
The function of miRNAs in the immune system's inflammatory reaction to heart failure.
作者信息
Yibulayin Kadierya, Abulizi Maidinaimu
机构信息
Graduate School of Xinjiang Medical University, Urumqi, China.
出版信息
Front Cardiovasc Med. 2024 Dec 2;11:1506836. doi: 10.3389/fcvm.2024.1506836. eCollection 2024.
Abstract
Heart failure is the end stage of cardiovascular disease, with high morbidity and mortality rates worldwide. Heart failure is associated with long-term and insufficient inhibition of inflammatory response. miRNA is a class of endogenous, non-coding, single-stranded small RNA molecules, that can regulate gene expression through translational inhibition or degradation of targeted mRNA, widely regulate myocardial remodeling, inflammatory response, and other pathological processes, and play an important regulatory role in the occurrence and development of cardiovascular diseases. This article reviews the role of miRNA in the inflammatory response in heart failure.
摘要
心力衰竭是心血管疾病的终末期，在全球范围内具有较高的发病率和死亡率。心力衰竭与炎症反应的长期抑制不足有关。微小RNA（miRNA）是一类内源性、非编码的单链小RNA分子，可通过抑制翻译或降解靶向信使核糖核酸（mRNA）来调节基因表达，广泛调节心肌重塑、炎症反应等病理过程，并在心血管疾病的发生和发展中发挥重要的调节作用。本文综述了miRNA在心力衰竭炎症反应中的作用。
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