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伴有骨成分的上肢去分化脂肪肉瘤：一种罕见的病理学情况。

Upper Extremity Dedifferentiated Liposarcoma With an Osseus Component: An Uncommon Pathology.

作者信息

Ihionkhan Emmanuel, Marcucci Vincent, Grille Victoria, Alexander Peter, Gibbs John

机构信息

Neurosurgery, Hackensack University Medical Center, Hackensack, USA.

Surgery, Jersey Shore University Medical Center, Neptune, USA.

出版信息

Cureus. 2024 Nov 15;16(11):e73735. doi: 10.7759/cureus.73735. eCollection 2024 Nov.

DOI:10.7759/cureus.73735
PMID:39687824
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11647061/
Abstract

Liposarcomas are the most common soft tissue sarcoma primarily originating in deep soft tissues and the retroperitoneum. Sarcoma classification includes atypical lipomatous tumor/well-differentiated liposarcoma (WDL) and dedifferentiated liposarcoma (DDL), myxoid liposarcoma, and pleomorphic liposarcoma. DDL is most prevalent in the retroperitoneum and often has two distinct components, a well-differentiated lipomatous component and a dedifferentiated nonlipomatous component that could be morphologically similar to malignant fibrous histiocytoma (MFH) or fibrosarcoma. DDLs can undergo heterologous differentiation into multiple cancer types including rhabdomyosarcoma, chondrosarcoma, melanoma, and leiomyosarcoma. Rarely, DDLs can undergo metaplastic bone formation. We report a peculiar case of a DDL with an osseous component.

摘要

脂肪肉瘤是最常见的软组织肉瘤，主要起源于深部软组织和腹膜后间隙。肉瘤分类包括非典型脂肪瘤性肿瘤/高分化脂肪肉瘤（WDL）和去分化脂肪肉瘤（DDL）、黏液样脂肪肉瘤和多形性脂肪肉瘤。DDL在腹膜后最常见，通常有两个不同的成分，一个高分化的脂肪瘤性成分和一个去分化的非脂肪瘤性成分，后者在形态上可能类似于恶性纤维组织细胞瘤（MFH）或纤维肉瘤。DDL可发生异源性分化，形成多种癌症类型，包括横纹肌肉瘤、软骨肉瘤、黑色素瘤和平滑肌肉瘤。DDL很少能发生化生骨形成。我们报告了一例伴有骨成分的DDL特殊病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f0/11647061/39b7d3ed898a/cureus-0016-00000073735-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f0/11647061/1ec159bd753e/cureus-0016-00000073735-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f0/11647061/3b0db8054ad8/cureus-0016-00000073735-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f0/11647061/9b7f037f1d34/cureus-0016-00000073735-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f0/11647061/39b7d3ed898a/cureus-0016-00000073735-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f0/11647061/1ec159bd753e/cureus-0016-00000073735-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f0/11647061/3b0db8054ad8/cureus-0016-00000073735-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f0/11647061/9b7f037f1d34/cureus-0016-00000073735-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f0/11647061/39b7d3ed898a/cureus-0016-00000073735-i04.jpg

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本文引用的文献

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Biology and Management of Dedifferentiated Liposarcoma: State of the Art and Perspectives.去分化脂肪肉瘤的生物学特性与管理：现状与展望
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Dedifferentiated Liposarcoma: A Comprehensive Historical Review With Proposed Evidence-based Guidelines Regarding a Diagnosis in Need of Further Clarification.去分化脂肪肉瘤：全面的历史回顾及对进一步明确诊断需求的循证建议。
Adv Anat Pathol. 2021 Nov 1;28(6):426-438. doi: 10.1097/PAP.0000000000000314.
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Well-differentiated liposarcoma and dedifferentiated liposarcoma: An updated review.
高分化脂肪肉瘤和去分化脂肪肉瘤：最新综述。
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Dedifferentiated liposarcoma with peculiar meningothelial-like whorling and metaplastic bone formation.伴有特殊脑膜上皮样漩涡状结构和化生骨形成的去分化脂肪肉瘤。
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Ann Surg. 2006 Sep;244(3):381-91. doi: 10.1097/01.sla.0000234795.98607.00.
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MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data.MDM2和CDK4免疫染色在诊断高分化和去分化脂肪肉瘤亚型中是有用的辅助手段：对559例软组织肿瘤与基因数据的比较分析
Am J Surg Pathol. 2005 Oct;29(10):1340-7. doi: 10.1097/01.pas.0000170343.09562.39.
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Dedifferentiated liposarcoma.去分化脂肪肉瘤
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