Butt Fahad Rasool, Dhivagaran Thanansayan, Naqvi Syed
Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.
Department of Medical Imaging, Western University, Windsor, Ontario, Canada.
Radiol Case Rep. 2024 Nov 29;20(2):1095-1098. doi: 10.1016/j.radcr.2024.11.011. eCollection 2025 Feb.
Creutzfeldt-Jakob Disease (CJD) is a rare, fatal neurodegenerative disorder that is caused by prion proteins. Patients often present with rapidly progressive dementia, ataxia, myoclonus, memory impairment, visual problems, and changes in personality. In this case report, we aimed to address the course of a 62 year old female who presented with progressive decline in cognitive function and died within 6 months of presentation. The patient underwent cerebrospinal fluid testing, MRI brain, and electroencephalography during her stay in the hospital. Ultimately, an autopsy was performed, which demonstrated spongiform changes, neuronal loss, and astrogliosis, consistent with CJD.
克雅氏病（CJD）是一种罕见的致命性神经退行性疾病，由朊病毒蛋白引起。患者常表现为快速进展的痴呆、共济失调、肌阵挛、记忆障碍、视觉问题和人格改变。在本病例报告中，我们旨在阐述一名62岁女性患者的病程，该患者出现认知功能进行性下降，并在就诊后6个月内死亡。患者住院期间接受了脑脊液检查、脑部磁共振成像（MRI）和脑电图检查。最终进行了尸检，结果显示有海绵状改变、神经元丢失和星形胶质细胞增生，符合克雅氏病的表现。
