Universidade Federal de Pernambuco, Centro de Ciências Médicas, Departamento de Clínica Médica, Recife PE, Brazil.
Arq Neuropsiquiatr. 2022 Aug;80(8):837-844. doi: 10.1055/s-0042-1755341. Epub 2022 Oct 17.
The Creutzfeldt-Jakob disease (CJD) is a spongiform encephalopathy that manifests as a rapidly progressive dementia syndrome. Currently, CJD has no cure, and many patients die within the first year, but some drugs are being studied as options for managing this condition.
To evaluate the effectiveness of pharmacological treatments offered to patients with CJD as a means to increase survival and reduce cognitive deterioration.
A systematic review of the literature was performed using 4 independent reviewers and 1 extra reviewer to resolve possible divergences in the search and analysis of papers indexed in MedLINE (PubMed), SciELO and Lilacs databases. The Medical Subject Heading (MeSH) terms used were: , , , , , , , and , with the Boolean operators and . This search included controlled clinical trials, uncontrolled clinical trials, and case series published from the year 2000 onwards, in the English language.
A total of 85 papers were found using the descriptors used. At the end of the selection analyses, 9 articles remained, which were analyzed fully and individually.
None of the drugs evaluated proved significantly effective in increasing survival in patients with CJD. Flupirtine appears to have a beneficial effect in reducing cognitive deterioration in patients with CJD. However, additional studies are needed to establish better evidence and therapeutic options for the management of patients with CJD.
克雅氏病（CJD）是一种海绵状脑病，表现为迅速进展的痴呆综合征。目前，CJD 尚无治愈方法，许多患者在一年内死亡，但正在研究一些药物作为治疗这种疾病的选择。
评估为 CJD 患者提供的药物治疗的有效性，以提高生存率并减少认知恶化。
使用 4 名独立评审员和 1 名额外评审员对文献进行系统评价，以解决在搜索和分析 MedLINE（PubMed）、SciELO 和 Lilacs 数据库中索引的论文时可能出现的分歧。使用的医学主题词 (MeSH) 术语为：Creutzfeldt-Jakob 病、克雅氏病、诊断、治疗、预后、临床试验、随机对照、前瞻性研究，以及布尔运算符 AND 和 OR。该搜索包括 2000 年以来发表的对照临床试验、非对照临床试验和病例系列，语言为英语。
使用上述描述符共发现 85 篇论文。在选择分析结束时，剩下 9 篇文章，对其进行了全面和单独的分析。
评估的药物均未显著有效提高 CJD 患者的生存率。氟吡汀似乎对减少 CJD 患者的认知恶化有有益作用。然而，需要进一步的研究来为 CJD 患者的管理建立更好的证据和治疗选择。
