Samei Ehsan, Abadi Ehsan, Bakic Predrag, Bliznakova Kristina, Bosmans Hilde, Carton Ann-Katherine, Frangi Alejandro F, Glick Stephen, Lo Joseph Y, Kinahan Paul, Maidment Andrew, Ria Francesco, Sechopoulos Ioannis, Segars William Paul, Tanaka Rie, Vancoillie Liesbeth
CVIT Radiology, Duke University, Durham, North Carolina, USA.
Radiology, Lund University, Malmo, Sweden.
Med Phys. 2025 Mar;52(3):1950-1959. doi: 10.1002/mp.17587. Epub 2024 Dec 17.
The rapid advancement of medical technologies presents significant challenges for researchers and practitioners. While traditional clinical trials remain the gold standard, they are often limited by high costs, lengthy durations, and ethical constraints. In contrast, in-silico trials and digital twins have emerged not only as efficient and ethical alternatives but also as a complementary technology that can extend beyond classical trials to predict and design new strategies. The successful application of digital twins in industries like nuclear energy, automotive engineering, and aviation underscores their potential in human health.
In April 2024, Duke University hosted the first international summit on Virtual Imaging Trials in Medicine (VITM). The summit brought together over 130 experts from academia, industry, and regulatory bodies to discuss the latest developments, challenges, and future directions in this field. The event featured plenary speakers, presentations, and panel discussions, emphasizing the integration of clinical and in-silico methods to enhance medical evaluations.
Key takeaways included the necessity of diverse and realistic digital patient representations, the integration of physics and biology in simulations, and the development of robust validation frameworks. The summit also highlighted the importance of regulatory science and the establishment of Good Simulation Practices to ensure the credibility and reliability of virtual trials.
The key discussions and insights from the VITM summit underscore the potential of in-silico trials to revolutionize medical research and patient care through personalized, efficient, and ethical evaluation methods. The collaborative efforts and recommendations from this summit aim to drive future advancements in virtual imaging trials in medicine.
医学技术的快速发展给研究人员和从业者带来了重大挑战。虽然传统临床试验仍然是金标准，但它们往往受到高成本、长周期和伦理限制的制约。相比之下，计算机模拟试验和数字孪生不仅作为高效且符合伦理的替代方案出现，而且作为一种补充技术，可以超越传统试验来预测和设计新策略。数字孪生在核能、汽车工程和航空等行业的成功应用凸显了它们在人类健康领域的潜力。
2024年4月，杜克大学主办了首届医学虚拟成像试验国际峰会（VITM）。该峰会汇聚了来自学术界、工业界和监管机构的130多位专家，讨论该领域的最新进展、挑战和未来方向。活动包括全会发言、报告和小组讨论，强调临床和计算机模拟方法的整合以加强医学评估。
主要收获包括需要多样化和逼真的数字患者表征、在模拟中整合物理和生物学，以及开发强大的验证框架。峰会还强调了监管科学的重要性以及建立良好模拟实践以确保虚拟试验的可信度和可靠性。
VITM峰会的关键讨论和见解强调了计算机模拟试验通过个性化、高效和符合伦理的评估方法革新医学研究和患者护理的潜力。本次峰会的合作努力和建议旨在推动医学虚拟成像试验的未来发展。
