三维超短回波时间磁共振成像扫描显示的骨软骨异常与膝关节软骨退变相关。

Osteochondral Abnormalities on Three-Dimensional Ultrashort Echo Time MRI Scans Are Associated with Knee Cartilage Degradation.

作者信息

Lee Sunmin, Kim Yeo Ju, Lee Seunghun, Ryu Jeongah, Lee Ha Young, Jang Hyungseok, Tae Hui-Woon, Kim Jiyeong

机构信息

From the Department of Radiology, Hanyang University Hospital, 222-1 Wangsimni-ro, Seongdong-gu, Seoul 04763, South Korea (Sunmin Lee, Y.J.K., Seunghun Lee); Department of Radiology, Hanyang University Guri Hospital, Guri, South Korea (J.R.); Department of Radiology, Eunpyeong St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea (H.Y.L.); Department of Radiology, University of California, Davis, Sacramento, Calif (H.J.); Biostatistics Laboratory, Medical Research Collaborating Center, Industry-University Cooperation Foundation, Hanyang University, Seoul, South Korea (H.W.T., J.K.); and Department of Pre-Medicine, College of Medicine, Hanyang University, Seoul, South Korea (J.K.).

出版信息

Radiology. 2024 Dec;313(3):e232363. doi: 10.1148/radiol.232363.

DOI:10.1148/radiol.232363

PMID:39688485

Abstract

Background The calcified cartilage layer and subchondral bone plate (SBP) contribute to osteoarthritis development. Three-dimensional (3D) ultrashort echo-time (UTE) MRI can help to evaluate calcified cartilage and SBP in various stages of cartilage degradation. Purpose To compare calcified cartilage and SBP abnormalities using 3D UTE MRI with cartilage degradation and osteochondral junction (OCJ) abnormalities observed at proton-density fast spin-echo with fat suppression (PDFS) MRI. Materials and Methods Between April 2018 and March 2019, 143 participants were prospectively enrolled in this study and underwent routine knee MRI with an additional sagittal 3D UTE MRI examination for chronic knee pain. The MRI scans were retrospectively analyzed by two musculoskeletal radiologists independently and at consensus. Cartilage degradation grades and OCJ abnormalities were evaluated at PDFS MRI. Calcified cartilage and SBP abnormalities were assessed at 3D UTE MRI by considering the location of cartilage degradation. The relationship between cartilage degradation grade and abnormalities of calcified cartilage and SBP was assessed using Spearman rank correlation analysis. The association between OCJ abnormalities on PDFS MRI scans and calcified cartilage and SBP abnormalities was analyzed using logistic regression models. Results In total, 143 knees (71 right and 72 left knees) from 143 participants (mean age, 50.8 years ± 17.6 [SD]; 72 male and 71 female participants) were analyzed. On 3D UTE MRI scans, calcified cartilage defects showed a moderate positive correlation with the cartilage degradation grade (ρ = 0.49-0.52; < .001). Calcified cartilage thinning (ρ = 0.2-0.3; < .001), SBP irregular thickening (ρ = 0.3-0.35; < .001), and defects (ρ = 0.34-0.42; < .001) exhibited a weak positive correlation with the cartilage degradation grade. OCJ abnormalities depicted at PDFS MRI were associated with calcified cartilage and SBP abnormalities ( < .05). Conclusion Calcified cartilage layer and SBP abnormalities at 3D UTE MRI were associated with cartilage degradation and OCJ abnormalities depicted at PDFS MRI. © RSNA, 2024

摘要

背景

钙化软骨层和软骨下骨板（SBP）与骨关节炎的发展有关。三维（3D）超短回波时间（UTE）磁共振成像（MRI）有助于评估软骨退变各阶段的钙化软骨和SBP。目的：使用3D UTE MRI比较钙化软骨和SBP异常情况与质子密度脂肪抑制快速自旋回波（PDFS）MRI观察到的软骨退变及骨软骨交界（OCJ）异常情况。材料与方法：2018年4月至2019年3月，143名参与者前瞻性纳入本研究，因慢性膝关节疼痛接受常规膝关节MRI检查及额外的矢状面3D UTE MRI检查。MRI扫描由两名肌肉骨骼放射科医生独立进行回顾性分析并达成共识。在PDFS MRI上评估软骨退变分级和OCJ异常。在3D UTE MRI上根据软骨退变位置评估钙化软骨和SBP异常。采用Spearman等级相关分析评估软骨退变分级与钙化软骨和SBP异常之间的关系。使用逻辑回归模型分析PDFS MRI扫描上的OCJ异常与钙化软骨和SBP异常之间的关联。结果：共分析了143名参与者的143个膝关节（71个右膝和72个左膝）（平均年龄50.8岁±17.6[标准差]；72名男性和71名女性参与者）。在3D UTE MRI扫描上，钙化软骨缺损与软骨退变分级呈中度正相关（ρ = 0.49 - 0.52；P <.001）。钙化软骨变薄（ρ = 0.2 - 0.3；P <.001）、SBP不规则增厚（ρ = 0.3 - 0.35；P <.001）和缺损（ρ = 0.34 - 0.42；P <.001）与软骨退变分级呈弱正相关。PDFS MRI上显示的OCJ异常与钙化软骨和SBP异常相关（P <.05）。结论：3D UTE MRI上的钙化软骨层和SBP异常与PDFS MRI上显示的软骨退变和OCJ异常相关。©RSNA，2024