Diab Lara, Al Kattar Sahar, Oueini Naim, Hawi Jihad, Chrabieh Antoine, Dosh Laura, Jurjus Rosalyn, Leone Angelo, Jurjus Abdo
Department of Anatomy, Cell Biology and Physiological Sciences, American University of Beirut, Beirut, Lebanon.
Department of Agriculture and Food Engineering, School of Engineering, Holy Spirit University, Kaslik, Jounieh, Lebanon.
Immunogenetics. 2024 Dec 17;77(1):9. doi: 10.1007/s00251-024-01366-4.
Syndecan-1 (SDC-1) is a transmembrane protein localized on the basolateral surface of epithelial cells, encompassing a core protein with heparin sulfate and chondroitin sulfate glycosaminoglycan side chains. SDC-1 is involved in a panoply of cellular mechanisms including cell-to-cell adhesion, extracellular matrix interactions, cell cycle modulation, and lipid clearance. Alterations in the expression and function of SDC-1 are implicated in numerous disease entities, making it an attractive diagnostic and therapeutic target. However, despite its broad involvement in several disease processes, the underlying mechanism contributing to its diverse functions, pathogenesis, and therapeutic uses remains underexplored. Therefore, this review examines the role of SDC-1 in health and disease, focusing on liver pathologies, inflammatory diseases, infectious diseases, and cancer, and sheds light on SDC-1-based therapeutic approaches. Moreover, it delves into the mechanisms through which SDC-1 contributes to these diseases, emphasizing cell-type specific mechanisms. By comprehensively summarizing the significance of SDC-1, its association with several diseases, and its underlying mechanisms of action, the findings of this review could inform future research directions toward the development of targeted therapies and early diagnosis for a multitude of disease entities.
Syndecan-1（SDC-1）是一种跨膜蛋白，定位于上皮细胞的基底外侧表面，包含一个带有硫酸乙酰肝素和硫酸软骨素糖胺聚糖侧链的核心蛋白。SDC-1参与多种细胞机制，包括细胞间黏附、细胞外基质相互作用、细胞周期调节和脂质清除。SDC-1的表达和功能改变与多种疾病相关，使其成为一个有吸引力的诊断和治疗靶点。然而，尽管它广泛参与多种疾病过程，但其发挥多种功能、发病机制及治疗用途的潜在机制仍未得到充分探索。因此，本综述探讨了SDC-1在健康和疾病中的作用，重点关注肝脏疾病、炎症性疾病、感染性疾病和癌症，并阐明基于SDC-1的治疗方法。此外，还深入研究了SDC-1导致这些疾病的机制，强调细胞类型特异性机制。通过全面总结SDC-1的重要性、其与多种疾病的关联及其潜在作用机制，本综述的结果可为未来针对多种疾病实体开发靶向治疗和早期诊断的研究方向提供参考。
