Hou Jiapu, Sun Ruiyang, Zhang Xue, Jia Wanyu, Li Peng, Song Chunlan
Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, 450052, China.
Pediatric Emergency Department, Children's Hospital Affiliated to Zhengzhou University, No. 1, South University Road, Erqi District, Zhengzhou, Henan, 450052, China.
Eur J Clin Microbiol Infect Dis. 2025 Feb;44(2):393-403. doi: 10.1007/s10096-024-05014-3. Epub 2024 Dec 17.
To investigate the clinical characteristics of Mycoplasma pneumoniae (MP) pneumonia (MPP) combined with pulmonary embolism (PE) in children.
291 hospitalized pediatric cases with MPP were enrolled from January 2018 to May 2024 and divided into the PE group (141 cases) and non-PE control group (150 cases). Clinical data of both groups were analyzed and compared.
C-reactive protein (CRP), D-dimer, lactate dehydrogenase (LDH), and interleukin 6 (IL-6) were significantly higher in the PE group than in the non-PE control group. There were 85 males and 56 females in the PE group. The PE group has male-to-female ratio of 3: 2,and hemoptysis was observed in 11 children (7.08%), chest pain in 29 children (20.60%), and pulmonary necrosis in 89 children (63.12%). In the receiver operator curve(ROC), the areas under the curve(AUC) for D-dimer, CRP, IL-6, and LDH were 0.964, 0.690, 0.632, and 0.765, respectively. In the ROC curve, the cutoff values for D-dimer, CRP, IL-6, and LDH were 0.8 µg/ml, 24.2 mg/L, 37.8 pg/ml, and 461 U/L, respectively.
A proportion of children with MP infection combined with PE show atypical clinical symptoms. Children with MPP and elevated D-dimer levels, IL-6, CRP, erythrocyte sedimentation rate (ESR), and LDH may be prone to develop PE.
探讨儿童支原体肺炎（MPP）合并肺栓塞（PE）的临床特征。
选取2018年1月至2024年5月住院的291例MPP患儿，分为PE组（141例）和非PE对照组（150例）。分析比较两组的临床资料。
PE组C反应蛋白（CRP）、D-二聚体、乳酸脱氢酶（LDH）和白细胞介素6（IL-6）明显高于非PE对照组。PE组男85例，女56例，男女比例为3∶2，11例（7.08%）患儿出现咯血，29例（20.60%）患儿出现胸痛，89例（63.12%）患儿出现肺坏死。在受试者工作特征曲线（ROC）中，D-二聚体、CRP、IL-6和LDH的曲线下面积（AUC）分别为0.964、0.690、0.632和0.765。在ROC曲线中，D-二聚体、CRP、IL-6和LDH的截断值分别为0.8 μg/ml、24.2 mg/L、37.8 pg/ml和461 U/L。
部分MP感染合并PE的儿童表现出非典型临床症状。MPP患儿且D-二聚体、IL-6、CRP、红细胞沉降率（ESR）和LDH水平升高者可能易发生PE。
