Jeong Harim, Luo Tianqi, Kang Minjoo, Garvey William Frederick, Blankenau George, Suk Ji-Woo, Tarzaben Mohadese, Hwang Soonjo
Department of Psychiatry, University of Nebraska Medical Center, 42nd and Emile, Omaha, 68198, NE, United States of America.
School of Psychology, University of Sheffield, Cathedral Court, 1 Vicar Lane, Sheffield, S1 2LT, United Kingdom.
Psychiatry Res Neuroimaging. 2025 Mar;347:111917. doi: 10.1016/j.pscychresns.2024.111917. Epub 2024 Dec 5.
This review examines neuroimaging studies on adolescent depression (AD) within the Research Domain Criteria (RDoC) framework, focusing on fMRI, DTI, and EEG findings. The research highlights disrupted connectivity in several neural networks-such as the affective, reward processing, cognitive control, and default mode networks-that underpin emotional and cognitive dysfunctions in AD. Notably, hypoconnectivity in the affective and cognitive control networks correlates with deficits in emotional processing and executive functioning, while hyperactivity in the default mode network relates to excessive self-referential thoughts. Additionally, blunted reward responses and frontal-striatal connectivity are discussed alongside the therapeutic potential of cognitive behavioral therapy (CBT) to modulate these dysfunctional circuits. Despite these insights, variability in findings due to small sample sizes and diverse methodologies suggests a need for further research to validate neuroimaging biomarkers for treatment efficacy and to explore less studied treatments like ECT and TMS in this population. This review underscores the importance of integrating neuroimaging findings to enhance understanding and treatment of AD.
本综述在研究领域标准（RDoC）框架内审视了关于青少年抑郁症（AD）的神经影像学研究，重点关注功能磁共振成像（fMRI）、扩散张量成像（DTI）和脑电图（EEG）的研究结果。该研究突出了几个神经网络中连接性的破坏，如情感、奖赏处理、认知控制和默认模式网络，这些网络是AD中情绪和认知功能障碍的基础。值得注意的是，情感和认知控制网络中的连接不足与情绪处理和执行功能的缺陷相关，而默认模式网络中的过度活跃与过度的自我参照思维有关。此外，还讨论了迟钝的奖赏反应和额叶 - 纹状体连接，以及认知行为疗法（CBT）调节这些功能失调回路的治疗潜力。尽管有这些见解，但由于样本量小和方法多样导致研究结果存在差异，这表明需要进一步研究以验证神经影像学生物标志物对治疗效果的作用，并探索在该人群中较少研究的治疗方法，如电休克疗法（ECT）和重复经颅磁刺激（TMS）。本综述强调了整合神经影像学研究结果以加强对AD的理解和治疗的重要性。
