Zhang Yi-Jia-Ning, Xiao Yao, Li Zi-Zhan, Bu Lin-Lin
State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China.
State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China; Department of Oral & Maxillofacial - Head Neck Oncology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China.
Biochim Biophys Acta Mol Basis Dis. 2025 Mar;1871(3):167629. doi: 10.1016/j.bbadis.2024.167629. Epub 2024 Dec 15.
Immunotherapy has improved the survival rate of patients with head and neck squamous cell carcinoma (HNSCC), but less than 20 % of them have a durable response to these treatments. Excessive local recurrence and lymph node metastasis ultimately lead to death, making the 5-year survival rate of HNSCC still not optimistic. Cell metabolism has become a key determinant of the viability and function of cancer cells and immune cells. In order to maintain the enormous anabolic demand, tumor cells choose a specialized metabolism different from non-transformed somatic cells, leading to changes in the tumor microenvironment (TME). In recent years, our understanding of immune cell metabolism and cancer cell metabolism has gradually increased, and we have begun to explore the interaction between cancer cell metabolism and immune cell metabolism in a way which is meaningful for treatment. Understanding the different metabolic requirements of different cells that constitute the immune response to HNSCC is beneficial for revealing metabolic heterogeneity and plasticity, thereby enhancing the effect of immunotherapy. In this review, we have concluded that the relevant metabolic processes that affect the function of immune cells in HNSCC TME and proposed our own opinions and prospects on how to use metabolic intervention to enhance anti-tumor immune responses.
免疫疗法提高了头颈部鳞状细胞癌（HNSCC）患者的生存率，但其中不到20%的患者对这些治疗有持久反应。局部复发和淋巴结转移过多最终导致死亡，使得HNSCC的5年生存率仍然不容乐观。细胞代谢已成为癌细胞和免疫细胞生存能力及功能的关键决定因素。为了维持巨大的合成代谢需求，肿瘤细胞选择了一种不同于未转化体细胞的特殊代谢方式，导致肿瘤微环境（TME）发生变化。近年来，我们对免疫细胞代谢和癌细胞代谢的认识逐渐增加，并开始以对治疗有意义的方式探索癌细胞代谢与免疫细胞代谢之间的相互作用。了解构成对HNSCC免疫反应的不同细胞的不同代谢需求，有利于揭示代谢异质性和可塑性，从而增强免疫治疗效果。在本综述中，我们总结了影响HNSCC TME中免疫细胞功能的相关代谢过程，并就如何利用代谢干预增强抗肿瘤免疫反应提出了自己的观点和展望。
