Yen Kelvin, Miller Brendan, Kumagai Hiroshi, Silverstein Ana, Cohen Pinchas
Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, La Jolla, CA, USA.
Trends Genet. 2025 Feb;41(2):132-145. doi: 10.1016/j.tig.2024.11.010. Epub 2024 Dec 16.
Given the uniqueness of the mitochondria, and the fact that they have their own genome, mitochondrial-derived microproteins (MDPs) are similar to, but different from, nuclear-encoded microproteins. The discovery of an increasing number of microproteins from this organelle and the importance of mitochondria to cellular and organismal health make it a priority to study this novel class of proteins in search of possible therapeutic targets and cures. In this review, we discuss the history of MDP discovery, describe the function of each MDP, and conclude with future goals and techniques to help discover more MDPs.
鉴于线粒体的独特性，以及它们拥有自己的基因组这一事实，线粒体衍生的微蛋白（MDP）与核编码的微蛋白相似但又不同。从这个细胞器中发现越来越多的微蛋白，以及线粒体对细胞和机体健康的重要性，使得研究这类新型蛋白质以寻找可能的治疗靶点和治愈方法成为当务之急。在这篇综述中，我们讨论了MDP发现的历史，描述了每个MDP的功能，并以未来的目标和技术作为结尾，以帮助发现更多MDP。
