Aranzazu Ceballos Andrés David, María Martínez Sánchez Lina, Pamplona Sierra Ana Paulina, Vergara Yánez Daniela, Franco Hincapié Liliana, Baquero Rodriguez Richard
Universidad Pontificia Bolivariana, Medellín, Colombia.
Hospital Pablo Tobón Uribe, Medellín, Colombia.
Glob Pediatr Health. 2024 Dec 16;11:2333794X241307535. doi: 10.1177/2333794X241307535. eCollection 2024.
. Primary thrombotic microangiopathy includes hemolytic uremic syndrome caused by Shiga toxin-producing , atypical hemolytic uremic syndrome, and thrombotic thrombocytopenic purpura. . A retrospective study that included patients younger than 18 years diagnosed with primary thrombotic microangiopathy between 2011 and 2021. . Thirty patients were included, of which 63% corresponded to a hemolytic uremic syndrome caused by Shiga toxin-producing , and 30% to the atypical hemolytic uremic syndrome. The median age was 2.8 years and female sex predominated at 57%. On admission to the emergency room, fever and fatigue were the most frequent symptoms (93%), followed by oliguria and anuria (80%). 48% of patients received hemodialysis during their care. Mortality was estimated at 13%. . This study constitutes the largest series of primary thrombotic microangiopathy in the pediatric population of Latin America, where the etiological and clinical behavior of this condition is described.
原发性血栓性微血管病包括由产志贺毒素引起的溶血尿毒综合征、非典型溶血尿毒综合征和血栓性血小板减少性紫癜。一项回顾性研究纳入了2011年至2021年间诊断为原发性血栓性微血管病的18岁以下患者。共纳入30例患者，其中63%为产志贺毒素引起的溶血尿毒综合征，30%为非典型溶血尿毒综合征。中位年龄为2.8岁，女性占主导，为57%。急诊入院时，发热和疲劳是最常见的症状（93%），其次是少尿和无尿（80%）。48%的患者在治疗期间接受了血液透析。死亡率估计为13%。本研究是拉丁美洲儿科人群中最大的原发性血栓性微血管病系列研究，描述了该疾病的病因和临床行为。
