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姜黄素和运动可预防抑郁症，减轻海马体损伤，并改善慢性应激性抑郁症大鼠的抑郁样行为。

Curcumin and exercise prevent depression alleviating hippocampus injury and improve depressive-like behaviors in chronically stressed depression rats.

作者信息

Ahmadi Elaheh, Pourmotabbed Ali, Aghaz Nilofar, Nedaei Seyed Ershad, Veisi Mojgan, Salimi Zahra, Zarei Fatemeh, Jalili Cyrus, Moradpour Farshad, Zeinivand Motahareh

机构信息

Department of Physiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, I.R. Iran.

Department of Biology, Faculty of Science, University of Qom, Qom, I.R. Iran.

出版信息

Res Pharm Sci. 2024 Oct 22;19(5):509-519. doi: 10.4103/RPS.RPS_94_23. eCollection 2024 Oct.

DOI:10.4103/RPS.RPS_94_23
PMID:39691296
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11648346/
Abstract

BACKGROUND AND PURPOSE

Depression is a growing public health concern worldwide, characterized by cognitive impairment and structural abnormalities of the hippocampus. Current antidepressant treatment sometimes causes the late onset of results and the much faster occurrence of side effects. For this reason, the interest in new treatment strategies including exercise and natural products such as curcumin has increased to treat depression. The present study investigated the role of curcumin and exercise in improving depressive-like behavior and hippocampal damage induced by mild unpredictable chronic stress in male rats.

EXPERIMENTAL APPROACH

This study analyzed the effects of curcumin (100 mg/kg/day, P.O for 14 days) and exercise (treadmill running, 45 min/day for 14 days) on immobility behavior (forced swimming test), locomotor activity (open field test), anhedonia (sucrose preference test) and cell survival (Nissl staining) of the hippocampal CA3 region in chronically stressed depression rats.

FINDINGS/RESULTS: In the current study, curcumin treatment combined with exercise effectively improved immobility behavior, locomotor activity, and increased hippocampal cell survival resulted in preventing the development of hippocampus dysfunction and depressive-like behaviors.

CONCLUSION AND IMPLICATIONS

This study demonstrated a new prospect for treating depression. The current findings give researchers the confidence to continue the investigations on the effects of curcumin accompanied with exercise as a novel therapy for the treatment of depression.

摘要

背景与目的

抑郁症在全球范围内日益成为公共卫生问题，其特征为认知障碍和海马体结构异常。目前的抗抑郁治疗有时会导致起效延迟且副作用出现得更快。因此，包括运动和姜黄素等天然产物在内的新治疗策略治疗抑郁症的关注度有所增加。本研究调查了姜黄素和运动在改善雄性大鼠因轻度不可预测慢性应激诱导的抑郁样行为和海马损伤中的作用。

实验方法

本研究分析了姜黄素（100毫克/千克/天，口服，共14天）和运动（跑步机跑步，每天45分钟，共14天）对慢性应激抑郁大鼠在不动行为（强迫游泳试验）、运动活动（旷场试验）、快感缺失（蔗糖偏好试验）以及海马CA3区细胞存活（尼氏染色）方面的影响。

研究结果

在本研究中，姜黄素治疗联合运动有效改善了不动行为、运动活动，并增加了海马细胞存活，从而预防了海马功能障碍和抑郁样行为的发展。

结论与意义

本研究展示了治疗抑郁症的新前景。目前的研究结果让研究人员有信心继续研究姜黄素联合运动作为治疗抑郁症的新疗法的效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a2b/11648346/0f79e15a15df/RPS-19-509-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a2b/11648346/a578580a4d23/RPS-19-509-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a2b/11648346/05a62ec46b0d/RPS-19-509-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a2b/11648346/8070715bbf36/RPS-19-509-g003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a2b/11648346/0f79e15a15df/RPS-19-509-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a2b/11648346/a578580a4d23/RPS-19-509-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a2b/11648346/05a62ec46b0d/RPS-19-509-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a2b/11648346/8070715bbf36/RPS-19-509-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a2b/11648346/164f8f8ce03e/RPS-19-509-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a2b/11648346/0f79e15a15df/RPS-19-509-g005.jpg

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Rethinking data treatment: The sucrose preference threshold for anhedonia in stress-induced rat models of depression.
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The role and mechanism of NLRP3 inflammasome-mediated astrocyte activation in dehydrocorydaline against CUMS-induced depression.NLRP3炎性小体介导的星形胶质细胞激活在脱氢紫堇碱抗慢性应激诱导抑郁中的作用及机制
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