Elijaha Isaac, Samsam Aseela, Rafiei Arash, Patel Trushar, Song Sang-Eun
Burnett School of Biomedical Sciences, University of Central Florida, USA.
Lake Erie College of Osteopathic Medicine, Bradenton, USA.
J Cancer Biol Res. 2024;11(1). Epub 2024 Feb 29.
The examination of the prostate biopsy procedure is essential in the optimization of the diagnostic pathway of such a prevalent affliction as prostate cancer among men worldwide. With the core needle biopsy being the standard of care for the diagnosis of prostate cancer, the ability to obtain quality core samples is directly related to patient treatment and diagnostic reliability. Needle deflection and dynamic tissue deformation are two chief sources of unrepresentative samples outside of human error. To assess how these factors affect overall histological sample quality and what variables influence deflection and deformation, a review of related literature was conducted. A literature search using keywords [(core prostate) OR (prostate)] AND [(biopsy) OR (needle)] AND [(histological) OR (fragmentation) OR (deflection) OR (deformation)] AND [(factors) OR (rate) OR (quality)]. The resulting articles were analysed for relevance of factors influencing histological sample quality. The objective of this review was to analyse trends in the literature and comprise a comprehensive analysis regarding the factors that positively and negatively affect the final histological quality of the core specimens. The results highlighted the velocity of needle insertion into the soft tissue as a variable affecting dynamic deformation, and the geometry of the bevelled biopsy needle tip combined with the application of a biopsy template impacting the deviation of the needle from the linear target. Friction forces also significantly influence the final product as related to these factors. This literature study highlights the crucial parameters of the biopsy procedure and provides for a basis to discuss the improvements to the system and its external components to improve overall patient care. This suggests further investigation of these factors through their manipulation in controlled environments is necessary to improve the effectiveness of the biopsy procedure.
前列腺活检程序的检查对于优化全球男性中如此普遍的疾病——前列腺癌的诊断途径至关重要。由于核心针吸活检是前列腺癌诊断的标准治疗方法，获取高质量核心样本的能力直接关系到患者的治疗和诊断可靠性。除人为误差外，针的偏斜和动态组织变形是导致样本不具代表性的两个主要原因。为了评估这些因素如何影响整体组织学样本质量以及哪些变量会影响偏斜和变形，我们对相关文献进行了综述。使用关键词[(核心前列腺)或(前列腺)]与[(活检)或(针)]与[(组织学)或(破碎)或(偏斜)或(变形)]与[(因素)或(比率)或(质量)]进行文献检索。对所得文章分析影响组织学样本质量的因素的相关性。本综述的目的是分析文献中的趋势，并对正面和负面影响核心标本最终组织学质量的因素进行全面分析。结果突出了针插入软组织的速度作为影响动态变形的一个变量，以及斜面活检针尖端的几何形状与活检模板的应用对针偏离线性目标的影响。摩擦力也与这些因素相关，对最终结果有显著影响。这项文献研究突出了活检程序的关键参数，并为讨论改进系统及其外部组件以改善整体患者护理提供了基础。这表明有必要通过在受控环境中对这些因素进行操控来进一步研究它们，以提高活检程序的有效性。
