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前列腺癌病理学:近期进展与争议

Prostate Cancer Pathology: Recent Updates and Controversies.

作者信息

Sehn Jennifer K

机构信息

Jennifer K. Sehn, MD, is Assistant Professor, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri.

出版信息

Mo Med. 2018 Mar-Apr;115(2):151-155.

PMID:30228708
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6139855/
Abstract

Prostate cancer is common, and recent efforts in clinical management have focused on identifying patients who could be candidates from less aggressive management or who could benefit from more aggressive therapy. As prostate cancer histology, especially Gleason score, plays a critical role in predicting patient outcomes, attempts have been made to refine histologic classification and reporting in prostate cancer to facilitate patient risk stratification. This review discusses recent updates in prostate cancer grading and reporting.

摘要

前列腺癌很常见,近期临床管理方面的努力主要集中在识别那些可能适合采用较温和治疗方案的患者,或者那些可能从更积极的治疗中获益的患者。由于前列腺癌组织学,尤其是 Gleason 评分,在预测患者预后方面起着关键作用,因此人们一直在尝试完善前列腺癌的组织学分类和报告,以促进患者风险分层。本综述讨论了前列腺癌分级和报告的最新进展。

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本文引用的文献

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Am J Surg Pathol. 2017 Apr;41(4):e1-e7. doi: 10.1097/PAS.0000000000000820.
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Integrating Tertiary Gleason 5 Patterns into Quantitative Gleason Grading in Prostate Biopsies and Prostatectomy Specimens.将三级 Gleason 5 模式纳入前列腺活检和前列腺切除术标本的定量 Gleason 分级中。
Eur Urol. 2018 May;73(5):674-683. doi: 10.1016/j.eururo.2017.01.015. Epub 2017 Jan 20.
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Histologic Grading of Prostatic Adenocarcinoma Can Be Further Optimized: Analysis of the Relative Prognostic Strength of Individual Architectural Patterns in 1275 Patients From the Canary Retrospective Cohort.前列腺腺癌的组织学分级可进一步优化:对来自金丝雀回顾性队列的1275例患者中个体结构模式的相对预后强度分析
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Am J Surg Pathol. 2016 Oct;40(10):1400-6. doi: 10.1097/PAS.0000000000000691.
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